Azanidazole

Azanidazole Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Triclose,Ist. Chemioter.,Italy,1977

• Verwenden

  Antiprotozoal.

• Definition

  ChEBI: Azanidazole is a member of imidazoles and a C-nitro compound.

• Manufacturing Process

  Into a mixture of 1.6 g of 2-amino-4-methylpyrimidine with 10 ml of glacial acetic acid is slowly added 2.13 g of concentrated sulfuric acid. A mixture of 2.4 g of 2-formyl-1-methyl-5-nitroimidazole in 20 ml of glacial acetic acid is slowly added to the mixture of the pyrimidine under stirring. The reaction mixture is maintained at a temperature of about 55°C for 4 hours. The resultant mixture is then diluted with 200 ml of distilled water and neutralized with a saturated aqueous solution of sodium bicarbonate. A brownish-yellow precipitate (MP 232° to 235°C) is formed and recovered. The product is analyzed by infrared spectroscopy and is found to conform to 2-amino-4-[2- (1-methyl-5-nitro-2-imidazolyl)vinyl]pyrimidine.

• Therapeutic Function

  Antiprotozoal, Antibacterial

• Sicherheitsprofil

  Moderately toxic byintraperitoneal route. Mildly toxic by ingestion.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits toxicfumes of NOx.

Azanidazole Upstream-Materialien And Downstream Produkte

Azanidazole Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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