Hexadecan-1-ol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P304+P340：BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P405：Unter Verschluss aufbewahren.

1-Hexadecanol Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R38:Reizt die Haut.
  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S22:Staub nicht einatmen.
  S24/25:Berührung mit den Augen und der Haut vermeiden.
  S37:Geeignete Schutzhandschuhe tragen.

• Beschreibung

  1-Hexadecanol is a waxy white powder or flake form at room temperature, and is insoluble in water and soluble in alcohols and oils. Discovered by Chevrenl in 1913, It is one of the oldest known long-chain alcohol. It can be produced from the reduction of palmitic acid. 1-Hexadecanol may be contained in cosmetic and personal care products such as shampoos, creams and lotions. it is mainly used as an opacifier, emulsifier, and thickening agent that alter the thickness of the liquid, and increase and stabilize the foaming capacity.

• Chemische Eigenschaften

  Cetyl alcohol occurs as waxy, white flakes, granules, cubes, or castings. It has a faint characteristic odor and bland taste.

• Originator

  Hexadecyl alcohol,Esso Res. And Eng. Co.

• Occurrence

  Reported as a major constituent of spermaceti oil, where it is present chiefy as cetyl palmitate Also reported found in guava, peach, pear, kohlrabi, baked potato, mustard, Parmesan cheese, butter, milk powder, boiled egg, cooked chicken, roasted beef, beef fat, whiskies, tea, starfruit, mango, rice, licorice, kiwifruit, loquat, endive, shrimp, crab, clam, Cape gooseberry and pawpaw

• Verwenden

  cetyl alcohol is a versatile ingredient that can serve as an emollient, emulsifier, thickener, binder, foam booster, or emulsion stabilizer, depending on the formulation and need. It is derived from coconut or palm oil as well as being synthetically manufactured. It is considered by some sources to be a non-comedogenic material.

• Verwenden

  1-Hexadecanol has been used in preparation of:
  (±)-2-methoxyheptadecanoic acid (fatty acid)
  high-chain fatty acid esters of 1-hexadecanol, novel organic phase change material for thermal energy storage
  hexadecane (alkane) in the presence of membrane fraction of Vibrio furnissii M1

• Definition

  ChEBI: 1-Hexadecanol is a long chain fatty alcohol that is hexadecane substituted by a hydroxy group at position 1. It is a synthetic, solid, fatty alcohol and nonionic surfactant. It is used as an emulsifying agent in pharmaceutical preparations.

• Vorbereitung Methode

  Cetyl alcohol may be manufactured by a number of methods such as esterification and hydrogenolysis of fatty acids or by catalytic hydrogenation of the triglycerides obtained from coconut oil or tallow. Cetyl alcohol may be purified by crystallization and distillation.

• Therapeutic Function

  Pharmaceutic aid

• Synthesis Reference(s)

  The Journal of Organic Chemistry, 42, p. 512, 1977 DOI: 10.1021/jo00423a025
  Synthetic Communications, 25, p. 1901, 1995 DOI: 10.1080/00397919508015865
  Tetrahedron Letters, 24, p. 4485, 1983 DOI: 10.1016/S0040-4039(00)85933-X

• Allgemeine Beschreibung

  1-Hexadecanol is a free fatty acid alcohol generally used as an emulsifier, emollient, opacifier and surfactant in cosmetics formulations.

• Flammability and Explosibility

  Not classified

• Sicherheit(Safety)

  Cetyl alcohol is mainly used in topical formulations, although it has also been used in oral and rectal preparations.
  Cetyl alcohol has been associated with allergic delayed-type hypersensitivity reactions in patients with stasis dermatitis. Crosssensitization with cetostearyl alcohol, lanolin, and stearyl alcohol has also been reported. It has been suggested that hypersensitivity may be caused by impurities in commercial grades of cetyl alcohol since highly refined cetyl alcohol (99.5%) has not been associated with hypersensitivity reactions.
  LD₅₀ (mouse, IP): 1.6 g/kg
  LD₅₀ (mouse, oral): 3.2 g/kg
  LD₅₀ (rat, IP): 1.6 g/kg
  LD₅₀ (rat, oral): 5 g/kg

• Lager

  Cetyl alcohol is stable in the presence of acids, alkalis, light, and air; it does not become rancid. It should be stored in a well-closed container in a cool, dry place.

• läuterung methode

  Crystallise the alcohol from aqueous EtOH or from cyclohexane. Alternatively purify it by zone refining. The purity can be checked by gas chromatography. [Beilstein 1 H 429, 1 I 219, 1 II 466, 1 III 1815, 1 IV 1876.]

• Inkompatibilitäten

  Incompatible with strong oxidizing agents. Cetyl alcohol is responsible for lowering the melting point of ibuprofen, which results in sticking tendencies during the process of film coating ibuprofen crystals.

• Regulatory Status

  Included in the FDA Inactive Ingredients Database (ophthalmic preparations, oral capsules and tablets, otic and rectal preparations, topical aerosols, creams, emulsions, ointments and solutions, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

1-Hexadecanol Upstream-Materialien And Downstream Produkte

Hexadecan-1-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(579)Suppliers

36653-82-4, 1-Hexadecanol Verwandte Suche: