Thiophen-2-ethylamin

Bezeichnung:Thiophen-2-ethylamin

CAS-Nr30433-91-1

Englisch Name:Thiophene-2-ethylamine

CBNumberCB4853460

SummenformelC6H9NS

Molgewicht127.21

MOL-Datei30433-91-1.mol

Synonyma

Thiophen-2-ethylamin

Thiophen-2-ethylamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	202 °C
Siedepunkt	200-201 °C/750 mmHg (lit.)
Dichte	1.087 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.551(lit.)
Flammpunkt	190 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	DMSO, Methanol
pka	9.47±0.10(Predicted)
Aggregatzustand	Liquid
Wichte	1.087
Farbe	Colorless to yellow
Sensitive	Air Sensitive
BRN	106962
InChIKey	HVLUYXIJZLDNIS-UHFFFAOYSA-N
CAS Datenbank	30433-91-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	20/21/22-36/37/38
S-Sätze:	26-36-37/39
RIDADR	NA 1993 / PGIII
WGK Germany	3
HazardClass	IRRITANT
HazardClass	8
PackingGroup	II
HS Code	29339900

Gefahreninformationscode (GHS)

Thiophene-2-ethylamine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
A colorless to yellow liquid with unstable properties requiring protection with nitrogen gas. It appears as a light yellow clear liquid, but turns red upon prolonged exposure.
Verwenden
[2-(Thiophene-2-yl)ethyl]amine is used in the synthesis of geldanamycin derivatives as HCV replication inhibitors targetting Hsp90.
Verwenden
2-Thiopheneethylamine (2-thiophene ethyl amine, 2-(thien-2-yl)ethylamine) is suitable to functionalize multiwall carbon nanotubes (MWCNT).
It may be used as a reactant in the synthesis of pyrimidine derivatives by reacting with various isothiocyanatoketones and acylguanidines derivatives by reacting with aroyl S-methylisothiourea.
Allgemeine Beschreibung
2-Thiopheneethylamine (2-(thiophen-2-yl)ethanamine) is an aromatic amine. It undergoes microwave induced condensation with iminodiacetic acid to form the corresponding piperazine-2,6-dione derivatives. Its effect as a probable substitute to the pyridine ligand on the performance of poly(3-hexylthiophene)/CdSe hybrid solar cells has been investigated.
Synthese
N,N-Dimethylformamide (DMF) reacts with thiophene to obtain 2-thiophenecarbaldehyde, then reacts with isopropyl chloroacetate to obtain 2-thiopheneacetaldehyde, and then reacts with hydroxylamine hydrochloride to obtain 2-thiopheneacetaldehyde oxime, and finally reduced to give 2-thiopheneethylamine.
Einzelnachweise
[1] M. BARWIOLEK. Structural and spectral studies of silver(I) complexes with new Schiff bases derived from 2-thiopheneethylamine and their application in thin layer deposition by spin and dip coating techniques[J]. Polyhedron, 2017, 124: Pages 12-21. DOI:10.1016/j.poly.2016.12.011.
[2] BHUSHAN D. VARPE S B J. Schiff Base of Isatin with 2-Thiopheneethylamine and Its Mannich Bases: Synthesis, Docking, and In Vitro Anti-Inflammatory and Antitubercular Activity[J]. Russian Journal of Bioorganic Chemistry, 2022, 48 2: 372-379. DOI:10.1134/S1068162022020030.
[3] JUN YAN LEK. Understanding the Effect of Surface Chemistry on Charge Generation and Transport in Poly (3-hexylthiophene)/CdSe Hybrid Solar Cells[J]. ACS Applied Materials & Interfaces, 2011, 3 2: 287-292. DOI:10.1021/am100938f.
[4] SANDEEP KUMAR. Efficient synthesis of piperazine-2,6-dione and 4-(1H-indole-2-carbonyl)piperazine-2,6-dione derivatives and their evaluation for anticancer activity[J]. Medicinal Chemistry Research, 2013, 22 10: 4600-4609. DOI:10.1007/s00044-012-0438-7.

Thiophene-2-ethylamine Upstream-Materialien And Downstream Produkte

Thiophen-2-ethylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

30433-91-1, Thiophene-2-ethylamine Verwandte Suche:

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