1-[1,3-DIMETHYL-4-(2-METHYLETHYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-6-YL]-4-(3,5-DICHLORO-4-PYRIDINYL)-SEMICARBAZIDE

1-[1,3-DIMETHYL-4-(2-METHYLETHYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-6-YL]-4-(3,5-DICHLORO-4-PYRIDINYL)-SEMICARBAZIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  JTE 013 is an antagonist of Sphingosine-1-Phosphate Receptor-2 (S1P2R).

• Biologische Aktivität

  Sphingosine-1-phosphate (S1P) receptor antagonist, highly selective for S1P 2 (EDG-5). Inhibits S1P binding to human S1P 2 receptors with an IC 50 value of 17.6 nM. At concentrations up to 10 μ M, displays 4.2% inhibition of S1P 3 and does not antagonize S1P 1 . Enhances S1P-induced angiogenesis in vivo .

1-[1,3-DIMETHYL-4-(2-METHYLETHYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-6-YL]-4-(3,5-DICHLORO-4-PYRIDINYL)-SEMICARBAZIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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