3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester

3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  COR659 is a potent positive allosteric modulator (PAM) of GABAB. It alleviates drug addiction to alcohol and chocolate in rats.

• in vitro

  COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABA _B receptor and an action at the cannabinoid CB1 receptor.

• in vivo

  COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats.
  It is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats.
  

  Animal Model:	Male sP and Wistar rats.
  Dosage:	0, 2.5, 5 and 10 mg/kg.
  Administration:	Intraperitoneally (administered 30 min before the start of the self-administration, reinstatement, and locomotor activity sessions.).
  Result:	The magnitude of the reducing effect of the compound on number of lever-responses for alcohol averaged approximately 30, 55, and 70%, in com parison to the vehicle-treated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively. The magnitude of the reducing effect of COR659 on number of lever-responses for alcohol averaged approximately 20, 40, and 80%, in comparison to the vehicletreated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively.

3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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