[2H3]- Vincristine Sulfate Struktur

[2H3]- Vincristine Sulfate

Bezeichnung:[2H3]- Vincristine Sulfate

CAS-Nr1217854-24-4

Englisch Name:[2H3]- Vincristine Sulfate

CBNumberCB48009197

SummenformelC46H58N4O14S

Molgewicht923.04

MOL-Datei1217854-24-4.mol

[2H3]- Vincristine Sulfate physikalisch-chemischer Eigenschaften

storage temp.	Store at -20°C, protect from light, stored under nitrogen
Löslichkeit	Methanol (Slightly), Water (Slightly)
Aggregatzustand	Solid
Farbe	White to Pale Beige
Stabilität	Hygroscopic

[2H3]- Vincristine Sulfate Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Labelled Vincristine. An antitumor alkaloid isolated from Vinca rosea Linn. An antineoplastic.
Biologische Aktivität
Vincristine-d3-ester (Leurocristine-d3-ester) sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM[1]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
Einzelnachweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Jordan, M.A., et al. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res, 1985. 45(6): p. 2741-7. [3]. Gidding, C.E., et al, Vincristine revisited. Crit Rev Oncol Hematol, 1999. 29(3): p. 267-87. [4]. Donoso, J.A., et al, Action of the vinca alkaloids vincristine, vinblastine, and desacetyl vinblastine amide on axonal fibrillar organelles in vitro. Cancer Res, 1977. 37(5): p. 1401-7. [5]. Horton, J.K., et al. Relationships between tumor responsiveness, vincristine pharmacokinetics and arrest of mitosis in human tumor xenografts. Biochem Pharmacol, 1988. 37(20): p. 3995-4000. [6]. Baguley, B.C., et al, Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism. Eur J Cancer, 1991. 27(4): p. 482-7. [7]. Zhang D, et al. Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance. Int J Nanomedicine. 2017 Mar 16;12:2081-2108.

[2H3]- Vincristine Sulfate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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