2-Chlor-4,6-dimethoxy-1,3,5-triazin

Bezeichnung:2-Chlor-4,6-dimethoxy-1,3,5-triazin

CAS-Nr3140-73-6

Englisch Name:2-Chloro-4,6-dimethoxy-1,3,5-triazine

CBNumberCB4775597

SummenformelC5H6ClN3O2

Molgewicht175.57

MOL-Datei3140-73-6.mol

Synonyma

2-Chlor-4,6-dimethoxy-1,3,5-triazin

2-Chlor-4,6-dimethoxy-1,3,5-triazin physikalisch-chemischer Eigenschaften

Schmelzpunkt	71-74 °C (lit.)
Siedepunkt	99-100 °C (1 mmHg)
Dichte	1.7917 (rough estimate)
Dampfdruck	5.8Pa at 25℃
Brechungsindex	1.5870 (estimate)
Flammpunkt	99-100°C/1mm
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Chloroform, Methanol
Aggregatzustand	Crystalline Powder
pka	0.33±0.10(Predicted)
Farbe	White to almost white
Wasserlöslichkeit	insoluble
BRN	148988
InChIKey	GPIQOFWTZXXOOV-UHFFFAOYSA-N
LogP	2.105 at 25℃
CAS Datenbank	3140-73-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36/37-36
RIDADR	UN3077
WGK Germany	3
HS Code	29339900

Gefahreninformationscode (GHS)

2-Chloro-4,6-dimethoxy-1,3,5-triazine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
white to almost white crystalline powder
Verwenden
2-Chloro-4,6-dimethoxy-1,3,5-triazine is used as a peptide coupling agent for the purification of peptides. It is used in the synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride through coupling with N-methylmorpholine in tetrahydrofuran. Further, it plays an important role in the production of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, through reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine. In addition to this, it is involved in the preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts through reaction with various tertiary amines.
Verwenden
2-Chloro-4,6-dimethoxy-1,3,5-triazine may be used in the following studies:
- The specific labeling of streptavidin by the modular method for affinity labeling (MoAL).
- The preparation of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, via reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine.
- The preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts, via reaction with various tertiary amines.
- The synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, via coupling with N-methylmorpholine in THF.
Allgemeine Beschreibung
2-Chloro-4,6-dimethoxy-1,3,5-triazine is a stable, yet highly reactive, peptide coupling agent. It is reported as useful coupling reagent for the purification of peptides. Catalytic amide-forming reactions of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. Procedure for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported.
Synthese
A preparation method of 2-chloro-4,6-dimethoxy-1,3,5-triazine comprises the following steps: using cyanuric chloride and sodium methoxide solid as reaction raw materials and N, N-dimethylformamide as a reaction solvent, gradually heating to obtain a 2-chloro-4,6-dimethoxy-1,3,5-triazine crude product, and finally, recrystallizing with heptane for purification. The reaction temperature is controlled to prepare the product, and the yield is up to 91%.

2-Chloro-4,6-dimethoxy-1,3,5-triazine Upstream-Materialien And Downstream Produkte

2-Chlor-4,6-dimethoxy-1,3,5-triazin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

3140-73-6, 2-Chloro-4,6-dimethoxy-1,3,5-triazine Verwandte Suche:

Send Inquriy