Benzylisothiocyanat

Bezeichnung:Benzylisothiocyanat

CAS-Nr622-78-6

Englisch Name:BENZYL ISOTHIOCYANATE

CBNumberCB4767442

SummenformelC8H7NS

Molgewicht149.21

MOL-Datei622-78-6.mol

Synonyma

Benzylisothiocyanat

Benzylisothiocyanat physikalisch-chemischer Eigenschaften

Schmelzpunkt	41 °C
Siedepunkt	242-243 °C(lit.)
Dichte	1.125 g/mL at 25 °C(lit.)
FEMA	4428 \| BENZYL ISOTHIOCYANATE
Brechungsindex	n20/D 1.6018(lit.)
Flammpunkt	>235 °F
storage temp.	2-8°C
Löslichkeit	0.1g/l
Aggregatzustand	Liquid
Wichte	1.125
Farbe	Clear yellow
Geruch (Odor)	at 0.10 % in dipropylene glycol. mild watercress dusty medicinal horseradish oily
Geruchsart	watercress
Wasserlöslichkeit	Hydrolyzes in water.
Sensitive	Moisture Sensitive
JECFA Number	1562
BRN	386135
InChIKey	MDKCFLQDBWCQCV-UHFFFAOYSA-N
LogP	3.16
CAS Datenbank	622-78-6(CAS DataBase Reference)
EPA chemische Informationen	Benzene, (isothiocyanatomethyl)- (622-78-6)

Sicherheit

Kennzeichnung gefährlicher	Xn,C,T
R-Sätze:	20/21/22-36/37/38-42/43
S-Sätze:	26-36/37/39
RIDADR	2810
WGK Germany	3
RTECS-Nr.	NX8250000
F	8-19-21
Hazard Note	Corrosive/Harmful/Store under nitrogen
TSCA	T
HazardClass	8
PackingGroup	III
HS Code	29309090
Toxizität	mmo-sat 150 mg/plate ABCHA6 44,3017,80

Gefahreninformationscode (GHS)

BENZYL ISOTHIOCYANATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
clear yellow liquid
Chemische Eigenschaften
Pale yellowish liquid; strong, penetrating aroma.
Occurrence
Reported found in common cress, Lepidium sativum, nasturtium, and Tropaeolum majus.
Verwenden
A novel medical application of isothiocyanate ester in treating various leukemia, with low toxicity, which includes benzyl isothiocyanate, phenylethyl isothiocyanate, allyl isothiocyanate, sulforaphane, and erucin. Benzyl isothiocyanate (BITC) inhibits the growth of human pancreatic cancer cells by inducing apoptosis.
Verwenden
Benzyl isothiocyanate has been used in the preparation of S-(N-benzylthiocarbamoyl)-L-glutathione and S-(N-benzylthiocarbamoyl)-L-cysteine.
Verwenden
antineoplastic, antibacterial, antifungal
Definition
ChEBI: Benzyl isothiocyanate is an isothiocyanate and a member of benzenes. It has a role as an antibacterial drug.
synthetische
Benzyl isothiocyanate is synthesized by the following two methods: I) from Benzylamine via Thiuramdisulfide via Sodiumsalt with Iodine to Benzyl-isothiocyanate. 2) from Benzylamine and Thiocarbonyl chloride.
Aroma threshold values
Medium strength odor, watercress type; recommend smelling in a 1.0% solution or less.
Synthesis Reference(s)
Tetrahedron Letters, 33, p. 7021, 1992 DOI: 10.1016/S0040-4039(00)60922-X
Allgemeine Beschreibung
Benzyl isothiocyanate is a naturally-occurring constituent of cruciferous vegetables. It has antibacterial properties and its metabolism in man has been investigated. It inhibits chemically induced cancer in animal models.
Hazard
Very irritant to tissues.
Biochem/physiol Actions
Odor at 1.0%: Vegetative cabbage and radishlike, green with a musty sulfurous earthiness reminiscent of mustard greens.Taste at 0.5ppm: Green vegetative cabbage, kimchi, radish and wasabi-like with green leafy nuances and imparting a strong trigeminal tongue numbing and raspy sensation.
Sicherheitsprofil
Poison by intraperitoneal andsubcutaneous routes. Intensely irritating. Mutation datareported. Moderate fire hazard via heat, flame, andoxidizers. To fight fire, use water, spray, foam, drychemical. When heated to decomposition it emits verytoxic NOx
Solubility in organics
Soluble in alcohol and oils.

BENZYL ISOTHIOCYANATE Upstream-Materialien And Downstream Produkte

Benzylisothiocyanat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

622-78-6, BENZYL ISOTHIOCYANATE Verwandte Suche:

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