N-Hydroxybenzamid

Bezeichnung:N-Hydroxybenzamid

CAS-Nr495-18-1

Englisch Name:Benzohydroxamic acid

CBNumberCB4764830

SummenformelC7H7NO2

Molgewicht137.14

MOL-Datei495-18-1.mol

Synonyma

N-Hydroxybenzamid

N-Hydroxybenzamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	126-130 °C(lit.)
Siedepunkt	251.96°C (rough estimate)
Dichte	1.2528 (rough estimate)
Brechungsindex	1.5030 (estimate)
storage temp.	2-8°C
Löslichkeit	Soluble in alcohol. Slightly soluble in ether. Insoluble in benzene.
Aggregatzustand	Solid
pka	pK1: 8.89(0) (20°C)
Farbe	Rhombic tablets
Wasserlöslichkeit	22 g/L (6 ºC)
BRN	1907585
Stabilität	Moisture and Temperature Sensitive
InChIKey	VDEUYMSGMPQMIK-UHFFFAOYSA-N
CAS Datenbank	495-18-1(CAS DataBase Reference)
NIST chemische Informationen	Benzamide, n-hydroxy-(495-18-1)
EPA chemische Informationen	Benzohydroxamic acid (495-18-1)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	68-40-20/21/22
S-Sätze:	45-36/37-36-22
WGK Germany	3
RTECS-Nr.	DF9650000
TSCA	Yes
HS Code	29280090
Toxizität	LD orl-rat: >500 mg/kg NCNSA6 5,26,53

Gefahreninformationscode (GHS)

Benzohydroxamic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R68:Irreversibler Schaden möglich.
R40:Verdacht auf krebserzeugende Wirkung.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S22:Staub nicht einatmen.
Chemische Eigenschaften
Crystalline Solid
Verwenden
Benzhydroxamic acid may be employed for the Pd-catalyzed synthesis of benzisoxazolones.
Verwenden
Benzhydroxamic acid is used as precursor in the synthesis of novel mono-anionic and di-anionic hydroxamato complexes by reacting with BiPh3 and Bi(O(t)Bu)3, which has anti-bacterial activity against helicobacter pylori. It is used in the photometric determination of trace amounts of vanadium in alloy steels by making mixed-ligand vanadium chelates with ammonium thiocyanate. It is also involved in the palladium catalyzed synthesis of benzisoxazolones.
synthetische
To a rapidly stirred suspension of 19.6 gm (0.35 mole) of powdered anhydrous potassium hydroxide in 120 ml of pyridine, maintained at 0-5°C, is a added a solution of 13.9 gm (0.2 mole) of hydroxylamine hydrochloride in 100 ml of pyridine.
While maintaining the reaction temperature at 0-5°C, 15 gm (0.1 mole) of ethyl benzoate is added. Vigorous stirring is continued at room temperature for 6 hr. Then the solids are filtered off. The solids are washed with cold water to remove inorganic coproducts. The remainder, recrystallized from aqueous ethanol, represents a 94% yield of potassium benzohydroxamate.
This salt is triturated with cold 0.01 TV hydrochloric acid. From this mixture, by the usual procedures, 12.5 gm (91% overall) of benzohydroxamic acid is isolated, m.p. 131°C (from aqueous alcohol).
Synthesis Reference(s)
Tetrahedron Letters, 33, p. 5055, 1992 DOI: 10.1016/S0040-4039(00)61187-5
Allgemeine Beschreibung
Rhombic crystals or light beige solid.
Air & Water Reaktionen
Slightly soluble in water.
Reaktivität anzeigen
Benzohydroxamic acid is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition Benzohydroxamic acid emits toxic fumes of nitrogen oxides.
Brandgefahr
Flash point data for Benzohydroxamic acid are not available; however, Benzohydroxamic acid is probably combustible.
Sicherheitsprofil
Moderately toxic by ingestion.Mutation data reported. When heated to decomposition itemits toxic fumes of NOx.

Benzohydroxamic acid Upstream-Materialien And Downstream Produkte

N-Hydroxybenzamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

495-18-1, Benzohydroxamic acid Verwandte Suche:

Send Inquriy