5-(TETRADECYLOXY)-2-FUROIC ACID Struktur

5-(TETRADECYLOXY)-2-FUROIC ACID

Bezeichnung:5-(TETRADECYLOXY)-2-FUROIC ACID

CAS-Nr54857-86-2

Englisch Name:5-(TETRADECYLOXY)-2-FUROIC ACID

CBNumberCB4759746

SummenformelC19H32O4

Molgewicht324.45

MOL-Datei54857-86-2.mol

5-(TETRADECYLOXY)-2-FUROIC ACID physikalisch-chemischer Eigenschaften

Schmelzpunkt	112-115 °C
Siedepunkt	441.7±25.0 °C(Predicted)
Dichte	1.003±0.06 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	DMSO: 2.5 mg/mL
Aggregatzustand	solid
pka	3.55±0.10(Predicted)
Farbe	white to beige
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Sicherheit

WGK Germany	2
RTECS-Nr.	LU0288000
HS Code	29321900

5-(TETRADECYLOXY)-2-FUROIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
TOFA (54857-86-2) interferes with fatty acid synthase via inhibition of acetyl Co-A carboxylase (ACC1).1 Induces apoptosis in a variety of tumor cell lines.2,3 Stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells.4 TOFA impairs glucose-stimulated insulin secretion after chronic treatment.5
Verwenden
TOFA has been used as a lipid biosynthesis inhibitor in mesenchymal stromal cells (MSCs), human pluripotent stem cells., an acetyl-CoA carboxylase 1 inhibitor in murine adipocyte cell lines., a lipolysis inhibitor in cancer stem cells (CSCs).
Definition
ChEBI: A member of the class of furans that is 2-furoic acid in which the hydrogen at position 5 is replaced by a tetradecyloxy group.
Biochem/physiol Actions
5-(Tetradecyloxy)-2-furoic acid (TOFA) elicits hypolipidemic?functionality by favoring fatty acid breakdown and at the same time preventing biosynthesis. It induces apoptosis in pancreatic cancer cells and favors tumor suppression.
Einzelnachweise
References/Citations: 1) Halvorson?et al. (1984),?Inhibition of fatty acid synthesis in isolated adipocytes by 5-tetradecyloxy)-2-furoic acid; Lipids,?19?851 2) Guseva?et al. (2011),?TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status; Cancer Biol. Ther.,?12?80 3) Zhou?et al. (2003),?Fatty acid synthesis inhibition triggers apoptosis during S phase in human cancer cells; Cancer Res.,?63?7330 4) Schmidt?et al. (1999),?Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family; Mol. Cell. Endocrinol.,?155?51 5) Ronnebaum?et al. (2008),?Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism; J. Biol. Chem.,?283?14248

5-(TETRADECYLOXY)-2-FUROIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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