Aluminiumorthophosphat

Bezeichnung:Aluminiumorthophosphat

CAS-Nr7784-30-7

Englisch Name:Aluminium phosphate

CBNumberCB4741378

SummenformelAlO4P

Molgewicht121.95

MOL-Datei7784-30-7.mol

Synonyma

Aluminiumorthophosphat

Aluminiummonophosphat

Aluminiumorthophosphat physikalisch-chemischer Eigenschaften

Schmelzpunkt	1500 °C
Dichte	2.56 g/mL at 25 °C (lit.)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Very slightly soluble in water, practically insoluble in alcohol. It dissolves in dilute solutions of mineral acids and alkali hydroxides.
Aggregatzustand	Powder
Wichte	2.566
Farbe	White
Wasserlöslichkeit	Insoluble
Merck	14,358
Solubility Product Constant (Ksp)	pKsp: 20.01
Dielectric constant	6.0（Ambient）
Expositionsgrenzwerte	ACGIH: TWA 1 mg/m3
InChI	InChI=1S/Al.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+3;/p-3
InChIKey	ILRRQNADMUWWFW-UHFFFAOYSA-K
SMILES	[Al+3].P([O-])([O-])([O-])=O
CAS Datenbank	7784-30-7(CAS DataBase Reference)
EPA chemische Informationen	Monoaluminum phosphate (7784-30-7)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34
S-Sätze:	26-36/37/39-45
RIDADR	UN 3260 8/PG 2
WGK Germany	1
RTECS-Nr.	TB6450000
TSCA	Yes
HazardClass	8
HS Code	28352990
Toxizität	LD50 oral in mouse: > 5gm/kg

Gefahreninformationscode (GHS)

Aluminium phosphate Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
WEISSES KRISTALLINES PULVER.
CHEMISCHE GEFAHREN
Zersetzung beim Erhitzen auf hohe Temperaturen unter Bildung giftiger Rauche mit Phosphoroxiden. Reagiert sehr heftig mit starken Säuren und starken Basen.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
INHALATIONSGEFAHREN
Eine belästigende Partikelkonzentration in der Luft kann beim Dispergieren schnell erreicht werden, besonders als Pulver.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Reizt möglicherweise mechanisch.
LECKAGE
Persönliche Schutzausrüstung: Atemschutzgerät, P1-Filter für inerte Partikel. Verschüttetes Material in abgedeckten Behältern sammeln.
R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Aluminium phosphate occurs in nature as the mineral, berlinite. Also, it occurs in nature in minerals, amblygonite, [NaAl(PO4)(OH)]; augelite, [Al2(PO4)(OH)3]; lazulite, [(Mg,Fe)Al2(PO4)2(OH)2]; variscite [(Al,Fe3+)(PO4)•2H2O]; and wavellite, [Al3(OH)3•(PO4)2•5H2O]. It is used as flux for ceramics; as cement in combination with calcium sulfate and sodium silicate; and in the manufacture of special glasses. It is also used in dried gel and therapeutically as an antacid.
Chemische Eigenschaften
Aluminum phosphate adjuvant is a white hydrogel that sediments slowly and forms a clear supernatant.
Chemische Eigenschaften
Aluminum orthophosphate is a white crystalline solid which is often used in liquid or gel form
Physikalische Eigenschaften
White powdery solid (rhombic plate); the mineral berlinite (AlPO₄) has hexagonal quartz-like structure; refractive index 1.546; mp > 1,500°C; density 2.566 g/cu³; insoluble in water and alcohol; Ksp 9.83x10^-10very slightly soluble in HCl or HNO3.
Occurrence
The compound occurs in nature as the mineral, berlinite. Also, it occurs in nature in minerals, amblygonite, [NaA_l(PO₄)(OH)]; augelite, [Al₂(PO₄)(OH)₃]; lazulite, [(Mg,Fe)Al₂(PO₄)₂(OH)₂]; variscite [(Al,Fe³⁺)(PO₄)?₂H₂O]; and wavellite, [Al₃(OH)₃?(PO4)₂?5H₂O]. It is used as flux for ceramics; as cement in combination with calcium sulfate and sodium silicate; and in the manufacture of special glasses. It is also used in dried gel and therapeutically as an antacid.
Verwenden
As a flux for ceramics, preparation of dental cement, cement with calcium sulfate and sodium silicate, special glasses, as gel in pharmacy.Aluminum phosphate is used as catalysts, molecular sieves, flux for ceramics and as a gel in pharmacy. It is employed in the preparation of dental cement, emollients and fire-resistant coating. It plays an important role as an anti-fouling agent in textile industry.
Verwenden
Antacid; vaccine adjuvant
synthetische
It is prepared by treating sodium aluminate with phosphoric acid.
Vorbereitung Methode
Aluminum phosphate adjuvant is formed by the reaction of a solution of aluminum chloride and phosphoric acid with alkali hydroxide.
Trademarks
Phosphaljel (Wyeth-Ayerst).
Allgemeine Beschreibung
A colorless liquid. Insoluble in water. Corrosive to metals and tissue.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
An acid. The resulting aqueous solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Hazard
Solutions are corrosive to tissue.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Brandgefahr
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Flammability and Explosibility
Non flammable
Pharmazeutische Anwendungen
Aluminum phosphate adjuvant is used in parenteral human and veterinary vaccines.It activates Th2 immune responses, including IgG and IgE antibody responses.
Clinical Use
Phalu Gel's main active ingredient is aluminum Phosphorus. Aluminum Phosphate works to reduce excess stomach acid. This gel suspension, when taken to the stomach, will form a protective layer on the surface of the gastrointestinal mucosa, similar to the effect of mucus or mucosal protective factors to help cover the stomach from the impact of fluids. The aluminum phosphate layer in the stomach has a smooth dispersion effect, going to the ulcers in the stomach and making them heal faster, making the patient feel more comfortable and less painful. Aluminum Phosphorus, when used, does not affect the intestinal absorption of Phosphorus. Phalu-Gel will quickly reduce the pain of stomach ulcers and the discomfort of excess acid, help heal the ulcers quickly, and make the patient feel comfortable right away.Aluminum hydroxide, aluminum phosphate, and potassium aluminum sulfate (alum) are used as adjuvants in vaccines designed to stimulate systemic immunity. Aluminum salts are used in DPT, pneumocccal conjugate, hepatitis A, papilloma, anthrax, and rabies vaccines. Like other systemic adjuvants, they form an insoluble depot and slowly release the antigen, which stimulates an antibody response.
Sicherheitsprofil
Corrosive to the eyes, skin, and mucous membranes. When heated to decomposition it emits toxic fumes of POx. Used as an antacid and as a cement component, flux for ceramics, dental cement, glass, and gels. See also ALUMINUM COMPOUNDS and PHOSPHATES
Sicherheit(Safety)
Aluminum phosphate adjuvant is intended for use in parenteral vaccines and is generally regarded as safe. It may cause mild irritation, dryness, and dermatitis on skin contact. It may also cause redness, conjunctivitis, and short-term mild irritation on eye contact. Ingestion of large amounts of aluminum phosphate adjuvant may cause respiratory irritation with nausea, vomiting, and constipation. Inhalation is unlikely, although the dried product may cause respiratory irritation and cough. Type I hypersensitivity reactions following parenteral administration have also been reported.
mögliche Exposition
Used as a flux in ceramics; in dental cements; in the manufacture of special glasses, paints and varnishes, cosmetics; making pulp and paper; as an antacid.
Lager
Aluminum phosphate adjuvant is stable for at least 2 years when stored at 4–308℃ in well-sealed inert containers. It must not be allowed to freeze as the hydrated colloid structure will be irreversibly damaged.
Versand/Shipping
UN1760 Corrosive liquids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name Required. UN3260 Corrosive solid, acidic, inorganic, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name Required.
Inkompatibilitäten
A strong oxidizer; keep away from combustible materials. Violent reaction with reducing agents; strong bases. Material is an inorganic acid and will react, possibly violently, with bases; corrosive to metals, some plastics and body tissues
Inkompatibilitäten
The point of zero charge is related directly to the Al : P atomic ratio. Therefore, the substitution of additional phosphate groups for hydroxyl groups will lower the point of zero charge. Substitution of carbonate, sulfate, or borate ions for hydroxyl groups will also lower the point of zero charge.
Regulatory Status
GRAS listed. Accepted for use in human and veterinary vaccines in Europe and the USA. The limits for use in human vaccines are 0.85 mg aluminum/dose (FDA) and 1.25 mg aluminum/dose (WHO). There are no established limits for use in veterinary vaccines. Reported in the EPA TSCA Inventory.

Aluminium phosphate Upstream-Materialien And Downstream Produkte

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