6-Chlornicotinsaeure

Bezeichnung:6-Chlornicotinsaeure

CAS-Nr5326-23-8

Englisch Name:6-Chloronicotinic acid

CBNumberCB4707499

SummenformelC6H4ClNO2

Molgewicht157.55

MOL-Datei5326-23-8.mol

Synonyma

6-Chlornicotinsaeure

6-Chlornicotinsaeure physikalisch-chemischer Eigenschaften

Schmelzpunkt	190 °C (dec.)(lit.)
Siedepunkt	241.15°C (rough estimate)
Dichte	0.5
Brechungsindex	1.5870 (estimate)
Flammpunkt	192°C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	deionized water: soluble
pka	3.24±0.10(Predicted)
Aggregatzustand	Crystalline Powder
Farbe	Off-white to beige
Wasserlöslichkeit	Soluble in water (2 mg/ml at 20°C), ethanol, methanol, DMSO, and slightly soluble in chloroform.
Decomposition	192 ºC
BRN	115993
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	UAWMVMPAYRWUFX-UHFFFAOYSA-N
CAS Datenbank	5326-23-8(CAS DataBase Reference)
NIST chemische Informationen	6-Chloronicotinic acid(5326-23-8)
EPA chemische Informationen	6-Chloronicotinic acid (5326-23-8)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-24/25-37/39
WGK Germany	3
TSCA	T
HazardClass	IRRITANT
HS Code	29333999

Gefahreninformationscode (GHS)

6-Chloronicotinic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Off-white to beige crystalline powder
Verwenden
6-Chloropyridine-3-carboxylic acid (6-chloronicotinic acid/6-CNA) has been used to study its photolytic and photocatalytic degradation. 6-CNA is a degradation product of neonicotinoid insecticides imidacloprid and acetamiprid and is known to appear in different environmental matrices. The product has been used as a media component during the isolation of 6-CNA degrading bacterial strain from imidacloprid-exposed soil samples.
Verwenden
6-Chloronicotinic acid is used as building block for different chemical synthesis. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors.
Definition
ChEBI: 6-Chloronicotinic acid is a member of pyridines and an aromatic carboxylic acid.
Allgemeine Beschreibung
6-Chloropyridine-3-carboxylic acid is a metabolite of the neonicotinoid pesticides, imidacloprid and acetamiprid and occurs in different environmental matrices.(3) It is widely used in agricultural crop protection, domestic insect control and environmental pest management.
Synthese
In a 1000ml flask, add 450g chlorobenzene, 100g 2-chloro-5-methylpyridine, and 3g catalyst cobalt acetate under stirring, heat the system to 80℃, introduce oxygen, and control the oxygen flow rate at 0.4L/min. React under this condition for 4 hours. After the reaction, cool the system to room temperature, filter, and dry to obtain a mixture of 119g 6-chloronicotinic acid and cobalt acetate. Place those mentioned above mixed crude product in a 1000ml flask, add 600g of recrystallization solvent methanol, stir and heat to reflux; wait for the 6-chloronicotinic acid crude product to dissolve completely, keep warm for 5min, slowly cool the system to 5℃, precipitate a white product, maintain this internal temperature and continue stirring for 1 hour, filter, wash the filter cake once with a small amount of cooled methanol, and dry the obtained damp product at 80℃ for 4 hours to obtain 98.5g 6-chloronicotinic acid, purity 99.52% (HPLC), yield 79.7%.
läuterung methode
Purify it by recrystallisation from hot H2O and sublime it in a vacuum. [Pechmann & Welsch Chem Ber 17 2384 1884, Herz & Murty J Org Chem 26 122 1961, Beilstein 22/2 V 177.]

6-Chloronicotinic acid Upstream-Materialien And Downstream Produkte

6-Chlornicotinsaeure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5326-23-8, 6-Chloronicotinic acid Verwandte Suche:

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