Endothelin-1 (human, porcine)

Bezeichnung:Endothelin-1 (human, porcine)

CAS-Nr117399-94-7

Englisch Name:Endothelin-1 (human, porcine)

CBNumberCB4706533

SummenformelC109H159N25O32S5

Molgewicht2491.9

MOL-Datei117399-94-7.mol

Endothelin-1 (human, porcine) physikalisch-chemischer Eigenschaften

Siedepunkt	2467.3±65.0 °C(Predicted)
Dichte	1.273±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	1% acetic acid: >1 mg/mL
Aggregatzustand	powder
Farbe	white
Wasserlöslichkeit	Soluble in water.
Merck	13,3610
InChIKey	ZUBDGKVDJUIMQQ-UHFFFAOYSA-N

Sicherheit

WGK Germany	3
RTECS-Nr.	KE9446500
F	3-10
HS Code	2937190000

Gefahreninformationscode (GHS)

Endothelin-1 (human, porcine) Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Endothelin-1 (human, porcine) has been used for coating wells in polystyrene ELISA plates. Potent agonist for ETA and ETB endothelia receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.
Biologische Funktion
Endothelins are a family of vasoactive peptides secreted by endothelial cells. The three major endothelin peptides are all composed of 21 amino acids. Endothelins are the most potent vasoconstrictors known. Contraction of vascular smooth muscle in response to endothelin is associated with an increase in intracellular calcium. Increases in endothelin levels have been reported in patients with vasospastic, hypoxic, and ischemic diseases.The two identified isoforms of endothelin receptors have differing affinity for the three endothelin peptides. Selective and nonselective endothelin receptor antagonists are in development for potential use in the treatment of hypertension and other disorders associated with increased vascular resistance.
Biologische Aktivität
Endothelin 1 (human, porcine) is an endogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide isolated from porcine endothelial cells. ET-1 is widely present at binding sites in blood vessels, heart, kidneys, adrenal glands, lungs, and brain, and its distribution is similar to endothelial cells.
Biochem/physiol Actions
Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.
Lager
-20°C (desiccate)

Endothelin-1 (human, porcine) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

117399-94-7, Endothelin-1 (human, porcine) Verwandte Suche:

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