1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

• Sicherheit

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Oncrasin 1 is a proapoptotic compound.

• Definition

  ChEBI: Oncrasin-1 is a member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations. It has a role as an apoptosis inducer and an antineoplastic agent. It is a member of indoles, a member of monochlorobenzenes and an arenecarbaldehyde.

• Biologische Aktivität

  Proapoptotic agent that induces abnormal nuclear aggregation of PKC ι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC 50 ≤ 3 μ M) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo .

• Lager

  +4°C

1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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