L-CYSTEINESULFINIC ACID MONOHYDRATE Struktur

L-CYSTEINESULFINIC ACID MONOHYDRATE

Bezeichnung:L-CYSTEINESULFINIC ACID MONOHYDRATE

CAS-Nr207121-48-0

Englisch Name:L-CYSTEINESULFINIC ACID MONOHYDRATE

CBNumberCB4503615

SummenformelHO2SCH2CH(NH2)CO2HH2O

Molgewicht171.17

MOL-Datei207121-48-0.mol

L-CYSTEINESULFINIC ACID MONOHYDRATE physikalisch-chemischer Eigenschaften

Schmelzpunkt	163 °C (dec.)(lit.)
storage temp.	-20°C
Löslichkeit	Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
Optische Aktivität	[α]25/D +24°, c = 1 in 1 M HCl
Stabilität	Temperature Sensitive

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
HS Code	2930901300

Gefahreninformationscode (GHS)

L-CYSTEINESULFINIC ACID MONOHYDRATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
L-Cysteinesulfinic acid is an excitatory amino acid and agonist of metabotropic glutamate receptors (mGluRs). It increases intracellular inositol phosphate levels in CHO cells expressing mGluR1, mGluR5, or mGluR8 (EC₅₀s = 120, 30, and 110 μM, respectively) and inhibits forskolin-induced cAMP production in CHO cells expressing mGluR2 or mGluR6 and hamster kidney cells expressing mGluR4 (EC₅₀s = 100, 100, and 2,000 μM, respectively). It selectively binds to mGluR1α (K_i = 3,510 nM) over adrenergic, dopamine, histamine, muscarinic, nicotinic, or serotonin receptors (K_is = >10,000 nM for all). L-Cysteinesulfinic acid (1 mM) decreases mean arterial blood pressure and heart rate in rats when microinjected into the nucleus tractus solitarius (NTS). L-Cysteinesulfinic acid can be formed via oxidation of L-cysteine by reactive oxygen species (ROS), and conversion of cysteine to L-cysteinesulfinic acid in cysteine-containing peptide probes has been used to measure oxidative stress.
Chemische Eigenschaften
Off-White Solid
Verwenden
L-Cysteinesulfinic acid monohydrate has been used in the fluorescence measurement of cysteine oxidation.
Verwenden
An amino acid derivative with neuropathological interest; Putative excitatory amino acid neurotransmitter.
Biochem/physiol Actions
Cysteinesulfinic acid (CSA), also called 3-sulfinoalanine is synthesized by the conversion of sulfur to sulfinic acid in cysteine by the enzyme cysteine dioxygenase (CDO). CSA is a putative excitatory amino acid (EAA) with neurotransmitter functionality. It also regulates cardiovascular functions.

L-CYSTEINESULFINIC ACID MONOHYDRATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

207121-48-0, L-CYSTEINESULFINIC ACID MONOHYDRATE Verwandte Suche:

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