Benzphetaminhydrochlorid

Bezeichnung:Benzphetaminhydrochlorid

CAS-Nr5411-22-3

Englisch Name:BENZPHETAMINE HYDROCHLORIDE--DEA

CBNumberCB4503206

SummenformelC17H21N.ClH

Molgewicht275.821

MOL-Datei5411-22-3.mol

Synonyma

Benzphetaminhydrochlorid

Benzphetaminhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	129-130°
Flammpunkt	11 °C
storage temp.	2-8°C
Löslichkeit	DMF: 3 mg/ml; DMSO: 5 mg/ml; Ethanol: 20 mg/ml; Methanol: 1 mg/ml; PBS (pH 7.2): 5 mg/ml
Aggregatzustand	A crystalline solid
EPA chemische Informationen	Benzphetamine hydrochloride (5411-22-3)

Sicherheit

Kennzeichnung gefährlicher	T,F
R-Sätze:	23/24/25-63-39/23/24/25-11
S-Sätze:	22-36/37/39-45-36/37-16
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	SG9625000
HS Code	2921460000

Gefahreninformationscode (GHS)

BENZPHETAMINE HYDROCHLORIDE--DEA Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Originator
Didrex,Upjohn,US,1960
Verwenden
The S-enantiomer of Benzphetamine (B209880). Controlled substance (stimulant). Anorexic.
Definition
ChEBI: The hydrochloride salt of benzphetamine. A sympathomimetic agent with properties similar to dextroamphetamine, it is used in the treatment of obesity.
Manufacturing Process
Fifty grams of d-desoxyephedrine hydrochloride was dissolved in a small amount of water and a molar excess of sodium hydroxide was .added thereto. The resulting forty grams of precipitated oily d-desoxyephedrine was collected in ether and the whole was thereafter dried with anhydrous potassium carbonate. The ether was then removed, the resulting oily residue having an nD22 of 1.5045 was stirred in a flask with 40 grams of anhydrous sodium carbonate at 120°C, and 34.6 grams of benzyl chloride was added dropwise thereto over a period of thirty minutes. Stirring was continued for 2 hours, whereafter the reaction mixture was extracted with benzene.
The benzene was distilled from the extract and the residue of d-N-methyl-Nbenzyl-β-phenylisopropylamine was distilled at reduced pressure. The thus obtained free base, distilling at 127°C at a pressure of 0.2 mm of mercury and having an nD19 of 1.5515, was dissolved in ethyl acetate and a molar equivalent of ethanolic hydrogen chloride was added thereto. Anhydrous ether was added to the mixture and d-N-methyl-N-benzyl-β-phenylisopropylamine hydrochloride precipitated from the reaction mixture as an oil which was crystallized from ethyl acetate to give crystals melting at 129° to 130°C.
Trademarks
Didrex (Pharmacia & Upjohn).
Therapeutic Function
Antiobesity

BENZPHETAMINE HYDROCHLORIDE--DEA Upstream-Materialien And Downstream Produkte

5411-22-3, BENZPHETAMINE HYDROCHLORIDE--DEA Verwandte Suche:

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