CITCO Struktur

CITCO

Bezeichnung:CITCO

CAS-Nr338404-52-7

Englisch Name:CITCO

CBNumberCB4497318

SummenformelC19H12Cl3N3OS

Molgewicht436.74

MOL-Datei338404-52-7.mol

CITCO physikalisch-chemischer Eigenschaften

Dichte	1.48±0.1 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	DMSO: 28 mg/mL, soluble
Aggregatzustand	solid
pka	4.05±0.40(Predicted)
Farbe	Light yellow to yellow

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3

Gefahreninformationscode (GHS)

CITCO Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
CITCO has been used for the activation of mouse constitutive androstane receptor (CAR) and human CAR.
Definition
ChEBI: 1-[6-(4-chlorophenyl)-5-imidazo[2,1-b]thiazolyl]-N-[(3,4-dichlorophenyl)methoxy]methanimine is a member of imidazoles.
Allgemeine Beschreibung
CITCO is an imidazothiazole derivative. It stimulates human constitutive androstane receptor (CAR) nuclear translocation.
Biologische Aktivität
citco, an imidazothiazole derivative, is a selective agonist of human car, with an ec50 value of 49 nm and > 50-fold selectivity to car over pregnane x receptor (pxr), and no activity on other nuclear receptors. upon activation with specific agonists, car translocates into the nucleus and binds to the response elements as monomers or car/rxr heterodimers. the car functions as a xenobiotic receptor, involved in detoxification and clearance of toxic substances from the liver. in addition, activation with selective car agonists such as citco has also been shown to inhibit growth and expansion of brain tumor stem cells.1. chakraborty s, kanakasabai s, bright jj. constitutive androstane receptor agonist citco inhibits growth and expansion of brain tumour stem cells. british journal of cancer, 2011, 104(3): 448-459.
Biochem/physiol Actions
CITCO is a constitutive androstane receptor (CAR) agonist; nuclear receptor NR113 agonist.
Lager
Desiccate at -20°C

CITCO Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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