Linocaine hydrochloride

Bezeichnung:Linocaine hydrochloride

CAS-Nr6108-05-0

Englisch Name:Linocaine hydrochloride

CBNumberCB4486868

SummenformelC14H25ClN2O2

Molgewicht288.82

MOL-Datei6108-05-0.mol

Linocaine hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	75-79℃
storage temp.	2-8°C
Löslichkeit	H₂O: soluble
Aggregatzustand	solid
Farbe	white
Wasserlöslichkeit	Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether.
InChI	InChI=1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2
InChIKey	YECIFGHRMFEPJK-UHFFFAOYSA-N
SMILES	C1(C(C)=CC=CC=1C)NC(=O)CN(CC)CC.O.Cl
LogP	2.359 (est)
CAS Datenbank	6108-05-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	AN7700000
TSCA	Yes
HazardClass	6.1
HS Code	2924296000

Gefahreninformationscode (GHS)

Linocaine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Linocaine hydrochloride is a white or almost white, crystalline powder with slightly bitter and numbing taste. Soluble in water, ethanol and organic solvents, insoluble in ether. The aqueous solution does not decompose under acid and alkali conditions, and it rarely deteriorates after repeated autoclaving.
Verwenden
Linocaine hydrochloride is a fast voltage-gated sodium channel blocker that used in Local anesthesia and heart rhythm disorders. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.
Application
Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.
Definition
ChEBI: Linocaine hydrochloride is the monohydrate form of lidocaine hydrochloride. It is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of Procaine but its duration of action is shorter than that of bupivacaine or prilocaine.
Trademarks
Alpha caine Hydrochloride (Carlisle); Anestacon (Polymedica); Laryng-O-Jet (International Medication); Lidocaton (Phar maton); Lidopen (Meridian); Xylocaine (Abraxis); Xylo caine (AstraZeneca); Xylocaine (Dentsply).
Kontakt-Allergie
Linocaine hydrochloride is an anesthetic of the amide group, like articaine or bupivacaine. Immediate-type IgE-dependent reactions are rare, and delayed-type contact dermatitis is exceptional. Cross-reactivity between the different amide anesthetics is not systematic.
Mode of action
Lidocaine Hydrochloride is the hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.

Linocaine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

6108-05-0, Linocaine hydrochloride Verwandte Suche:

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