Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  iMAC2 is a mitochondrial apoptosis-induced channel (MAC) inhibitor.

• Allgemeine Beschreibung

  A MAC (Mitochondrial Apoptosis-induced Channel) inhibitor iMAC1 (Cat. No. 196805) structural analog that is reported to be less potent than iMAC1 in blocking Bid-induced cytochrome c release in cell-free mitochondria preparations (40% vs. 77% inhibition with 5 μM respective inhibitor), but more effective than iMAC1 in inhibiting STS- (Cat. No. 569396 & 569397) induced cytochrome c release in intact FL5.12 cells (Complete vs ~35% inhibition with 5 μM respective inhibitor), presumably due to an enhanced permeability. iMAC2 is also shown to be a superior blocker of MAC-mediated current flow in reconstituted mitochondrial outer membrane patches from apoptotic FL5.12 cells (IC₅₀ = 28 vs 300 nM in the case of iMAC2 and iMAC1, respectively) and protect FL5.12 from STS-induced apoptosis (IC₅₀ = 2.5 μM).

• Lager

  Desiccate at RT

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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