PG 931

PG 931 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  PG-931 is an analog of SHU 9119 (HY-P0227). PG-931 is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist, more selective than hMC3R (IC50=55 nM) or hMC5R (IC50=2.4 nM). It can reverse hemorrhagic shock and prevent multiple organ damage in vivo in animal experimental models.

• in vivo

  PG-931 (intravenous injection; 13-10 ⁸ nmol/kg; single dose) produces a dose-dependent restoration of cardiovascular and respiratory functions, and improved survival in Wistar rats with haemorrhagic shock.

  Animal Model:	Wistar rats
  Dosage:	13-10 8 nmol/kg
  Administration:	Intravenous injection; single dose
  Result:	Exhibitd an anti-shock effect occurred at nanomolar doses.

• target

  IC50: 0.58 nM (melanocortin 4 receptor)IC50: 2.4 nM (melanocortin 5 receptor)IC50: 55 nM (melanocortin 3 receptor)

PG 931 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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