OUABAIN OCTAHYDRATE

Bezeichnung:OUABAIN OCTAHYDRATE

CAS-Nr11018-89-6

Englisch Name:OUABAIN OCTAHYDRATE

CBNumberCB4469924

SummenformelC29H60O20

Molgewicht728.77

MOL-Datei11018-89-6.mol

OUABAIN OCTAHYDRATE physikalisch-chemischer Eigenschaften

Schmelzpunkt	260 °C
storage temp.	room temp
Löslichkeit	H₂O: 10 mg/mL cold
Aggregatzustand	powder
Farbe	white
Optische Aktivität	[α]25/D 31 to 32.5° in H2O(lit.)
Wasserlöslichkeit	Soluble in water.
Sensitive	Light Sensitive
BRN	101712
Stabilität	Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
EPA chemische Informationen	Card-20(22)-enolide, 3-[(6-deoxy-.alpha.-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, octahydrate, (1.beta.,3.beta.,5.beta.,11.alpha.)- (11018-89-6)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/25-33
S-Sätze:	45
RIDADR	UN 1544 6.1/PG 1
WGK Germany	3
RTECS-Nr.	RN3850000
F	8
HazardClass	6.1(b)
PackingGroup	III
HS Code	29389090

Gefahreninformationscode (GHS)

OUABAIN OCTAHYDRATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/25:Giftig beim Einatmen und Verschlucken.
R33:Gefahr kumulativer Wirkungen.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Ouabain (11018-89-6) is a selective inhibitor of Na+ K+-ATPase isolated from Strophanthus gratus.1 Endogenous ouabain is found in human circulation.2 Displays cardiotonic and diuretic activity. May be used to induce hypertensive rat model.3?Cell permeable and active in vivo.
Chemische Eigenschaften
Ouabain is a white crystalline solid.
Chemische Eigenschaften
white to off-white crystalline powder
Verwenden
Ouabain octahydrate, is used as a tool to induce in vivo excitotoxicity. Ouabain, as well as other endogenous digitalis-like compounds, can down-regulate the expression of 14-3-3 proteins in rat lens.
Verwenden
antiarrhythmic, cardiotonic, hypertensive, Na/K ATPase inhibitor
Verwenden
A cardiac glycoside that inhibits Na(+)/K(+) ATPase. It regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1.
Verwenden
5HT2 receptor antagonist
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Biochem/physiol Actions
Ouabain has its specific binding site on integral proteins of the plasma membrane. Heart disease is treated using ouabain derivatives. Increased ouabain production is observed during exercise in humans. Abnormally high levels of ouabain are indicated in congestive heart failure and hypertension. Ouabain signalling affects intracellular calcium levels, which is known to activate nuclear factor κB (NFκB).
mögliche Exposition
Ouabain, similar to digitoxin, is used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter; enzyme inhibitor.
Versand/Shipping
UN1544 Alkaloids, solid, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
läuterung methode
It crystallises from water as the octahydrate. Dry it at 130o. It decomposes at 190o when dry. Store it in the dark as it is light sensitive, but it is stable in air. Its solubility (g/100mL) in H2O is 1.3 (~25o), 20 (~100o), and in EtOH it is 1.0 (~25o) and 12.5 (~78o). It is highly TOXIC as it is an inhibitor of cation transport and of Na+ and K+ ATPase. [Beilstein 18/5 V 625.]
Inkompatibilitäten
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.).
Einzelnachweise
1) Silva et al. (2012), New insights into the regulation of Na+,K(+)-ATPase by ouabain; Int. Rev. Cell. Mol. Biol., 294 99 2) Dvela et al. (2012), Endogenous ouabain regulates cell viability; Am. J. Physiol. Cell, Physiol., 302 C442

OUABAIN OCTAHYDRATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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