DIHYDROFOLIC ACID Struktur

DIHYDROFOLIC ACID

Bezeichnung:DIHYDROFOLIC ACID

CAS-Nr4033-27-6

Englisch Name:DIHYDROFOLIC ACID

CBNumberCB4432012

SummenformelC19H21N7O6

Molgewicht443.41

MOL-Datei4033-27-6.mol

DIHYDROFOLIC ACID physikalisch-chemischer Eigenschaften

Schmelzpunkt	>160°C (dec.)
Dichte	1.69±0.1 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	0.1 M NaOH: 10 mg/mL, slightly hazy, orange
pka	pKa 1.38(H2O t=25 I=0.10) (Occasionally);3.84(H2O t=25 I=0.10) (Occasionally)
Aggregatzustand	Solid
Farbe	Light Beige to Beige
Biologische Quelle	synthetic (organic)
BRN	69017
Stabilität	Air Sensitive, Hygroscopic, Temperature Sensitive

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3

Gefahreninformationscode (GHS)

DIHYDROFOLIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
antidote to methotrexate toxicity
Verwenden
Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).
Definition
ChEBI: Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a dihydrofolate(2-).
Allgemeine Beschreibung
Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase.
Biochem/physiol Actions
Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).
läuterung methode
DHFA is best purified by suspending (1g mostly dissolved)) in ice-cold sodium ascorbate (300mL of 10% at pH 6.0, prepared by adjusting the pH of 30g of sodium ascorbate in 150mL of H2O by adding 1N NaOH dropwise using a gla

DIHYDROFOLIC ACID Upstream-Materialien And Downstream Produkte

DIHYDROFOLIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

4033-27-6, DIHYDROFOLIC ACID Verwandte Suche:

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