CGP 20712 A

CGP 20712 A Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  CGP-20712A methanesulfonate salt has been used as a β1-adrenergic receptor antagonist in adult rat ventricular myocytes (ARVM) and rat cardiac fibroblasts. It may also be used as an antagonist for the β1-adrenergic receptor in rat bladder smooth muscles.

• Biologische Aktivität

  Highly selective and potent β 1 -adrenoceptor antagonist (IC 50 = 0.7 nM). Displays 10,000-fold selectivity over β 2 -adrenoceptors. Also available as part of the β -Adrenoceptor Antagonist Tocriset™ .

• Biochem/physiol Actions

  CGP-20712A methanesulfonate salt is a selective β1-adrenoceptor antagonist.

• in vitro

  In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.

• in vivo

  Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection.

CGP 20712 A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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