7-Ethoxycumarin

Bezeichnung:7-Ethoxycumarin

CAS-Nr31005-02-4

Englisch Name:7-Ethoxycoumarin

CBNumberCB4357665

SummenformelC11H10O3

Molgewicht190.2

MOL-Datei31005-02-4.mol

Synonyma

7-Ethoxycumarin

7-Ethoxycumarin physikalisch-chemischer Eigenschaften

Schmelzpunkt	88-90 °C (lit.)
Siedepunkt	265.69°C (rough estimate)
Dichte	1.1803 (rough estimate)
Brechungsindex	1.4260 (estimate)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	Off-White to Pale Brown
Wasserlöslichkeit	Soluble in hot methanol (very faint turbidity), 95% ethanol (50 mg/ml), DMF, and DMSO. Insoluble in water.
BRN	146200
LogP	2.310 (est)
CAS Datenbank	31005-02-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
S-Sätze:	22-24/25
WGK Germany	3
F	8
Hazard Note	Irritant
TSCA	Yes
HS Code	29329990

7-Ethoxycoumarin Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
BEIGE CRYSTALLINE POWDER
Verwenden
7-Ethoxycoumarin is a substrate for CYP2B6 used in fluorometric assays of microsomal monooxygenase activity.
Verwenden
7-Ethoxycoumarin is commonly used for metabolism studies, including hepatocyte studies, liver perfusion techniques and cytochrome P450 studies.
7-Ethoxycoumarin has been used to study the functional activity of recombinant P450. ) It has also been used as an internal standard for in vitro S-warfarin 7-hydroxylation and high performance liquid chromatography (HPLC) analysis.
Definition
ChEBI: 7-ethoxycoumarin is a member of the class of coumarins that is umbelliferone in which the hydroxy group at position 7 is replaced by an ethoxy group. It is an aromatic ether and a member of coumarins. It derives from an umbelliferone.
Biochem/physiol Actions
7-Ethoxycoumarin is a cytochrome P450 substrate.
Stoffwechsel
7-Ethoxycoumarin is metabolized by many cytochrome P450 enzymes active in foreign compound metabolism and has been used as a prototypic substrate to monitor P450 (P450) activity in both hepatic and extrahepatic tissues.
The in vitro perfusion of the human placental lobule with 7-ethoxycoumarin gives 7-hydroxycoumarin, and perfusion with androstenedione gives the conversion products, estrone, estradiol, and testosterone. The human placenta has only a limited capacity for the metabolism of xenobiotics.
Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYP1, CYP2, and CYP3 Families

7-Ethoxycoumarin Upstream-Materialien And Downstream Produkte

7-Ethoxycumarin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

31005-02-4, 7-Ethoxycoumarin Verwandte Suche:

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