2-Amino-6-fluorobenzoic acid

Bezeichnung:2-Amino-6-fluorobenzoic acid

CAS-Nr434-76-4

Englisch Name:2-Amino-6-fluorobenzoic acid

CBNumberCB4351052

SummenformelC7H6FNO2

Molgewicht155.13

MOL-Datei434-76-4.mol

2-Amino-6-fluorobenzoic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	167-169 °C (lit.)
Siedepunkt	223.67°C (rough estimate)
Dichte	1.3021 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	soluble in Methanol
pka	4.01±0.10(Predicted)
Aggregatzustand	Crystalline Powder
Farbe	Yellow to brown
BRN	3540926
InChIKey	RWSFZKWMVWPDGZ-UHFFFAOYSA-N
CAS Datenbank	434-76-4(CAS DataBase Reference)
NIST chemische Informationen	Anthralic acid, 6-fluoro-(434-76-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29224999

Gefahreninformationscode (GHS)

2-Amino-6-fluorobenzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
white to light yellow crystal powder
Verwenden
Used in the synthesis of a novel benzamide with potent neuroleptic activity. 5- fluoro-2-methyl-3,l-benzoxazin-4-one was obtained from 2-amino-6-fluorobenzoic acid. The condensation of 2-amino-6-fluorobenzoic acid methyl ester and (4-fluorophenyl) acetyl chloride with N,N-dimethylamino-4-pyridine in CH 2 Cl 2 to give 2-fluoro-6-[2-(4-fluoro-phenyl)-acetylamino]-benzoic acid methyl ester in 61% yield. 2 Amino 6 fluorobenzoic acid is another easily ac cessible synthon for construction of monofluorinated heterocycles. Reactions of 2,3,4,6-tetra-O-acetyl-n-D_glucopyranosyl bromide (2) with p-hydroxybenzaldehyde, trifluoromethyl and fluoro substi- tuted aniline and 2-amino-6-fluorobenzoic acid gave lO-(Pformyl- pheny1)-2,3,4,6-tetra-O-acetyl-(3-D-glucopyranoside. 2-Fluoro-6-iodobenzoic acid,a loose white crystal,was synthesized by using 2-amino-6-fluorobenzoic acid as the starting material.
Definition
ChEBI: 2-Amino-6-fluorobenzoic acid is an aminobenzoic acid.
Lager
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
Synthese
The synthesis of 2-Amino-6-fluorobenzoic acid is as follows:
A 50 ml three-necked flask was charged with 1.85 g (10 mmol) of 6-fluoro-2-nitrobenzoic acid, 25.6 mg (0.2 mmol) of molybdenum dioxide, and 76.8 mg of activated carbon. 30 ml of absolute ethanol was added dropwise 1.25 g (20 mmol) of hydrazine hydrate (80%) at room temperature. After the reaction was completed at room temperature for 7 h, TLC monitoring showed that the reaction was completed, filtered, and the filtrate was concentrated, then ethyl acetate (20 mL) and water (10 ml) were added and extracted. The organic phase was washed with water and concentrated to give 1.5g desired product as a pale yellow solid, yield 96.8%, HPLC purity 99.6%.

2-Amino-6-fluorobenzoic acid Upstream-Materialien And Downstream Produkte

2-Amino-6-fluorobenzoic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

434-76-4, 2-Amino-6-fluorobenzoic acid Verwandte Suche:

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