L-655,708

L-655,708 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner.

• Biologische Aktivität

  Potent, selective inverse agonist for the benzodiazepine site of GABA A receptors containing the α 5 subunit (K i = 0.45 nM). Displays 50-100-fold selectivity over GABA A receptors containing α 1, α 2, α 3 or α 6 subunits in combination with β 3 and γ 2. Enhances LTP in? a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.

• Biochem/physiol Actions

  L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats.

• Lager

  Desiccate at +4°C

L-655,708 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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