Citicolin

Bezeichnung:Citicolin

CAS-Nr987-78-0

Englisch Name:CYTIDINE 5'-DIPHOSPHOCHOLINE

CBNumberCB4343598

SummenformelC14H26N4O11P2

Molgewicht488.33

MOL-Datei987-78-0.mol

Synonyma

Citicolin

Citicolin physikalisch-chemischer Eigenschaften

Schmelzpunkt	>185°C (dec.)
alpha	D25 +19.0° (c = 0.86 in H2O)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	Water (Sparingly)
pka	4.4(at 25℃)
Aggregatzustand	Solid
Farbe	White
Stabilität	Moisture Sensitive
InChIKey	RZZPDXZPRHQOCG-APGYLPRWNA-N
SMILES	O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C=CC(N)=NC1=O)O \|&1:1,2,3,21,r\|
LogP	-7.070 (est)
CAS Datenbank	987-78-0(CAS DataBase Reference)

Sicherheit

Toxizität

LD50 in mice, rats (mg/kg): 4600 ±335, 4150 ±370 i.v.; both species 8 g/kg orally (Grau)

Gefahreninformationscode (GHS)

CYTIDINE 5'-DIPHOSPHOCHOLINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Nicholin,Cyanamid,Italy,1971
Verwenden
Cytidine 5'-Diphosphocholine is used as antidepressant, 5HT uptake inhibitor.
Definition
ChEBI: CDP-choline is a member of the class of phosphocholines that is the chloine ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes. It has a role as a human metabolite, a psychotropic drug, a neuroprotective agent, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is a member of phosphocholines and a member of nucleotide-(amino alcohol)s. It is functionally related to a CDP. It is a conjugate base of a CDP-choline(1+).
Manufacturing Process
A 250 ml conical flask containing 30 ml of a reaction liquor (pH 7.0) having a composition of 7.38 mg/ml of disodium salt of CMP (cytidine-5'- monophosphate), 24 mg/ml of choline, 10 mg/ml of glucose, 100 mg/ml of acetone-dried cells of Brevibacterium ammoniagenes ATCC 6872, 11.6 mg/ml of monopotassium phosphate, 20 mg/ml of dipotassium phosphate and 2.96 mg/ml of magnesium sulfate, (MgSO4·7H2O), was subjected to culturing at 30°C for 4 hours. Cytidine diphosphate choline was formed and accumulated at a concentration of 3.8 mg/ml in the culture liquor.
The pH of 1.2 liters of filtrate containing 3.8 mg/ml of cytidine diphosphate choline, obtained by removing solid matters from the culturing liquor, was adjusted to a pH of 8.5 with a 0.5 N KOH solution. The filtrate was passed through a column of strongly basic anion exchange resin, Dowex 1 x 2 (formic acid type). After washing the resin with water, a formic acid solution was passed through the column with gradual increase in the concentration of formic acid (until 0.04 N max.). A fraction of cytidine diphosphate choline was collected by elution according to the so-called gradient elution method and absorbed onto carbon powders. Then, elution was effected with acetone, and the eluate was concentrated and dried. 1.3 g of cytidine diphosphate choline powders were obtained.
Therapeutic Function
Cerebral circulation stimulant

CYTIDINE 5'-DIPHOSPHOCHOLINE Upstream-Materialien And Downstream Produkte

Citicolin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

987-78-0, CYTIDINE 5'-DIPHOSPHOCHOLINE Verwandte Suche:

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