N-[4-(Methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidyl]-N-phenylpropionamidcitrat

Bezeichnung:N-[4-(Methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidyl]-N-phenylpropionamidcitrat

Englisch Name:SUFENTANIL CITRATE

CBNumberCB4339496

SummenformelC28H38N2O9S

Molgewicht578.68

Synonyma

N-[4-(Methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidyl]-N-phenylpropionamidcitrat

N-[4-(Methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidyl]-N-phenylpropionamidcitrat physikalisch-chemischer Eigenschaften

Sicherheit

Kennzeichnung gefährlicher	T+,T,F
R-Sätze:	26/27/28-39/23/24/25-23/24/25-11
S-Sätze:	26-27-28-36/37/39-45-36/37-16-7
RIDADR	3249
WGK Germany	3
HazardClass	6.1(b)
PackingGroup	III
HS Code	2934910000
Toxizität	LD50 intravenous in dog: 14100ug/kg

Gefahreninformationscode (GHS)

Chemische Eigenschaften
Crystalline Solid
Verwenden
Potent derivative of Fentanyl. Analgesic (narcotic). Controlled substance (opiate)
Definition
ChEBI: Sufentanil citrate is an anilide.
Trademarks
Sufenta (Akorn).
Allgemeine Beschreibung
Sufentanil is a short acting synthetic opioid analgesic most commonly used for pain relief during medical operations. This certified solution standard is applicable to use in clinical toxicology, pain prescription monitoring, or forensic analysis by LC-MS/MS or GC/MS. Sufentanil is sold under the trade name Sufenta.
Clinical Use
Addition of the 4-methoxymethyl group and bioisosteric replacement of the phenyl with a 2-thiophenyl on the fentanyl structure results in a 10-fold increase in μ opioid activity. The resultant compound, sufentanil, is 600 to 800 times more potent than morphine. Despite its greater sedative and analgesic potency, sufentanil produces less respiratory depression at effective anesthetic doses. Sufentanil is available in an intravenous dosage form, and it is used for anesthetic procedures. It has a faster onset and shorter duration of action than fentanyl. The short duration is caused by redistribution from brain tissues after intravenous dosage.
Veterinary Drugs and Treatments
An opioid analgesic, sufentanil may be useful as an anesthesia adjunct or as an epidural analgesic. In humans, it has been used as the primary anesthetic in intubated patients with assisted ventilation, and as a post-operative analgesic.