7-Chlor-5-(2-fluorphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-on

Bezeichnung:7-Chlor-5-(2-fluorphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-on

CAS-Nr2886-65-9

Englisch Name:N-desalkylflurazepam

CBNumberCB4316060

SummenformelC15H10ClFN2O

Molgewicht288.7

MOL-Datei2886-65-9.mol

Synonyma

7-Chlor-5-(2-fluorphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-on

7-Chlor-5-(2-fluorphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	204-206°C
Siedepunkt	454.0±45.0 °C(Predicted)
Dichte	1.39±0.1 g/cm3(Predicted)
Flammpunkt	9℃
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	A neat solid
pka	11.55±0.70(Predicted)
Farbe	White to off-white
InChI	InChI=1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
InChIKey	UVCOILFBWYKHHB-UHFFFAOYSA-N
SMILES	N1C2=CC=C(Cl)C=C2C(C2=CC=CC=C2F)=NCC1=O
CAS Datenbank	2886-65-9(CAS DataBase Reference)
NIST chemische Informationen	Norfludiazepam(2886-65-9)

Sicherheit

Kennzeichnung gefährlicher	F,T
R-Sätze:	11-23/24/25-39/23/24/25
S-Sätze:	22-24/25-45-36/37-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	2
RTECS-Nr.	DF2370100
HS Code	2933997500

Gefahreninformationscode (GHS)

N-desalkylflurazepam Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Desalkylflurazepam (Item No. 18484) is an analytical reference material that is structurally categorized as a benzodiazepine. It is an active metabolite of several benzodiazepines, including flurazepam , flutoprazepam, fludiazepam, midazolam, and quazepam. Desalkylflurazepam inhibits L-type voltage-gated calcium channels (Ca_v; IC₅₀s = 55 and 37 μM for Ca_v1.2 and 1.3, respectively) by positively modulating GABA_A receptors. It can be detected in urine, serum, and meconium by LC-MS/MS. This product is intended for research and forensic applications.
Chemische Eigenschaften
Light Yellow Solid
Verwenden
The major human metabolite of flurazepam. This is a controlled drug precursor therefore a liscence may be required for purchase
Definition
ChEBI: Desalkylflurazepam is a benzodiazepine.
Allgemeine Beschreibung
N-Desalkylflurazepam (also known as norflurazepam, 2886-65-9) is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.
Mode of action
N-Desalkylflurazepam is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.

N-desalkylflurazepam Upstream-Materialien And Downstream Produkte

2886-65-9, N-desalkylflurazepam Verwandte Suche:

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