FIN56

FIN56 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  FIN56 (1083162-61-1) is a novel inducer of ferroptosis acting via degradation of GPX4 and activation of squalene synthase (leading to CoQ10 depletion, a compound which inhibits ferroptosis via an unknown mechanism).1? FIN56 inhibited glioblastoma growth in vitro and in vivo via induction of ferroptosis as well as lysosomal membrane permeabilization.2

• Definition

  ChEBI: FIN56 is a fluorene that is N-9H-fluoren-9-ylidenehydroxylamine substituted by N-cyclohexylsulfonyl groups at positions 2 and 7. It induces ferroptosis via degradation of GPX4 and also binds and activates squalene synthase. It has a role as a ferroptosis inducer and an EC 1.11.1.9 (glutathione peroxidase) inhibitor. It is a member of fluorenes, a ketoxime and a sulfonamide. It is functionally related to a 9-hydroxyiminofluorene-2,7-disulfonamide.

• Biochem/physiol Actions

  Ferroptosis inducer 56 (FIN56) is a member of the class 3 ferroptosis inducers.

• Lager

  Store at +4°C

• Einzelnachweise

  Shimada et al. (2016), Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis; Chem. Biol. 12 497 Zhang et al. (2021), FIN56, a novel ferroptosis inducer, triggers lysosomal membrane permeabilization in a TFEB-dependent manner in glioblastoma; Cancer 12 6610

FIN56 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(73)Suppliers

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