ODM-201 Struktur

ODM-201

Bezeichnung:ODM-201

CAS-Nr1297538-32-9

Englisch Name:ODM-201

CBNumberCB43052901

SummenformelC19H19ClN6O2

Molgewicht398.85

MOL-Datei1297538-32-9.mol

ODM-201 physikalisch-chemischer Eigenschaften

Schmelzpunkt	169 - 171°C
Siedepunkt	719.5±60.0 °C(Predicted)
Dichte	1.41±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer, Under inert atmosphere
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
pka	11.10±0.10(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White

Gefahreninformationscode (GHS)

ODM-201 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
ODM-201 is an androgen receptor (AR) antagonist (K_i = 11 nM). It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC₅₀s = 65, 66, 1,500, and 1,782 nM for wild-type, AR^F876L, AR^W741L, and AR^T877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC₅₀ = 230 nM). In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.
Beschreibung
ODM-201 is a novel androgen receptor (AR) inhibit designed to inhibit the growth of prostate cancer cells through binding to the AR to inhibit the testosterone-induced AR nuclear translocation. It is particularly used in patients with progressive metastatic castration-resistant prostate cancer. It is effective in inhibiting the activity of some mutant ARs emerging during antiandrogen therapies, including the F876L mutation version which is resistant to enzalutamide and ARN-509 (the second-generation antiandrogens).Therefore, it has potential to overcome the resistance issue occurring upon AR-targeted therapies.
Verwenden
ODM-201 is a compound being used as a novel next-generation androgen receptor-directed therapy for prostate cancer.
Einzelnachweise
Moilanen, Anu Maarit, et al. "Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies." Sci Rep 5.2(2015):12007. Fizazi, Karim, et al. "ODM-201, a new generation androgen receptor inhibitor for castration-resistant prostate cancer: Preclinical and phase I data." Genitourinary Cancers Symposium of the Conquer-Cancer-Foundation of 2013. Fizazi, K, et al. "Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial." Lancet Oncology 5.9(2014):975-85.

ODM-201 Upstream-Materialien And Downstream Produkte

ODM-201 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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