Platencin Struktur

Platencin

Bezeichnung:Platencin

CAS-Nr869898-86-2

Englisch Name:Platencin

CBNumberCB42703754

SummenformelC24H27NO6

Molgewicht425.474

MOL-Datei869898-86-2.mol

Platencin physikalisch-chemischer Eigenschaften

Siedepunkt	670.1±55.0 °C(Predicted)
Dichte	1.38±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
Löslichkeit	DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
Aggregatzustand	A solid
pka	2.14±0.13(Predicted)

Platencin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis, which is also the source of platensimycin . Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF. The IC₅₀ values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively. It does not exhibit cross-resistance to antibiotic resistant bacterial strains, including methicillin-resistant S. aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococci. For these reasons, platencin has potential applications in fighting antibiotic resistant bacteria.
Verwenden
Platencin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Platencin is more potent than its analogue, platensimycin. Platencin shows potent in vivo efficacy without any observed toxicity. Platencin targets two essential proteins, b-ketoacyl-acyl carrier protein (ACP) synthase II (FabF) and III (FabH) whereas platensimycin targets only FabF.
Verwenden
Platencin is a potent antibiotic that targets FabF and FabH proteins.
Definition
ChEBI: Platencin is a monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the polycyclic cage component. It is an antibiotic isolated from Streptomyces platensis and exhibits inhibitory activity against fatty acid synthase. It has a role as an antibacterial agent, an antimicrobial agent, an EC 2.3.1.85 (fatty acid synthase) inhibitor and a bacterial metabolite. It is a cyclic ketone, a polycyclic cage, a dihydroxybenzoic acid, a monocarboxylic acid amide and an aromatic amide. It is a conjugate acid of a platencin(1-).
Enzyminhibitor
This antibiotic (FW = 425.2 g/mol; CAS 869898-86-2; Soluble in ethanol, methanol, DMF or DMSO) inhibits both Staphylococcus aureus b-ketoacyl- [acyl-carrier-protein] synthases II and III, with IC50 values of 1.95 and 3.91 μg/mL, respectively. Platencin exhibits strong, broad-spectrum, Grampositive antibacterial activity to key antibiotic resistant strains, including methicillin-resistant Staphylococcus aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococcus faecium, without evidence of toxicity in humans.

Platencin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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