Terlipressin

Bezeichnung:Terlipressin

CAS-Nr14636-12-5

Englisch Name:Terlipressin acetate

CBNumberCB4266213

SummenformelC52H74N16O15S2

Molgewicht1227.37

MOL-Datei14636-12-5.mol

Synonyma

Terlipressin

Terlipressin physikalisch-chemischer Eigenschaften

Schmelzpunkt	>170°C (dec.)
Siedepunkt	1824.0±65.0 °C(Predicted)
Dichte	1.46±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	9.90±0.15(Predicted)
Farbe	White
Sequenz	Gly-Gly-Gly-c[Cys-Tyr-Phe-Gln-Asn-Cys]-Pro-Lys-Gly-NH2，(Disulfide bridge: Cys-Cys)
InChIKey	BENFXAYNYRLAIU-ITQMCZIINA-N
CAS Datenbank	14636-12-5(CAS DataBase Reference)

Sicherheit

HS Code

3504009000

Gefahreninformationscode (GHS)

Terlipressin acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Terlipressin acetate is a novel synthetic long-acting vasopressin preparation. It is a kind of prodrug, which is inactive by itself. After the action of aminopeptidase in the body, after removing the three glycyl residues at its N-terminus, it slowly "releases" the active lysine vasopressin. Therefore, terlipressin acts as a reservoir that releases lysine vasopressin at a steady rate.
Chemische Eigenschaften
N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin (Terlipressin acetate) is White Solid
Verwenden
Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It is used norepinephrine-resistant septic shock and hepatorenal syndrome. It is also used in the treatment of acute variceal bleeding. Terlipressin Acetate 1 mg solution for injection is used for the treatment of: bleeding from dilated (widening) veins in the food pipe leading to your stomach (called bleeding oesophageal varices).
Definition
ChEBI: Terlipressin is a polypeptide.
Clinical Use
Treatment of bleeding oesophageal varices
Nebenwirkungen
In clinical trials, the most common side effects of terlipressin administration were paleness, increased blood pressure, peripheral ischemia, abdominal pain, nausea, diarrhea, and headache.
Terlipressin related adverse events are common and most of terlipressin related adverse events were mild or moderate, which can be resolved spontaneously without any intervention. As terlipressin acts mainly on the splanchnic vessels, the incidence of severe ischemic complications is lower with terlipressin than with vasopressin. However, it may cause serious complications such as myocardial infarction, intestinal ischemia, peripheral cyanosis, and skin necrosis[1].
Stoffwechsel
Terlipressin is metabolised by tissue peptidases resulting in the slow release of lypressin. Terlipressin is almost completely metabolised in the kidneys and liver, with less than 1% of terlipressin and less than 0.1% of lypressin excreted in the urine.
Einzelnachweise
[1] Chiang C, et al. Terlipressin-Induced Peripheral Cyanosis in a Patient with Liver Cirrhosis and Hepatorenal Syndrome. American Journal of Case Reports, 2019.

Terlipressin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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