N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide

N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions. Anti-dementia properties[1].

• in vivo

  FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease^[2].

  Animal Model:	Male Lister Hooded rats, weighing approximately 270-300[2]
  Dosage:	0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg
  Administration:	Administered i.p.
  Result:	Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition.

• Einzelnachweise

  [1] Tokita K, et al. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. Eur J Pharmacol. 2005 Dec 19;527(1-3):111-20. DOI:10.1016/j.ejphar.2005.10.022
  [2] McCarthy AD, et al. FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease. Pharmacol Biochem Behav. 2011 Mar;98(1):76-80. DOI:10.1016/j.pbb.2010.11.019

N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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