Q-VD-OPh hydrate Struktur

Q-VD-OPh hydrate

Bezeichnung:Q-VD-OPh hydrate

CAS-Nr1135695-98-5

Englisch Name:Q-VD-OPh hydrate

CBNumberCB42652283

SummenformelC26H25F2N3O6

Molgewicht513.49

MOL-Datei1135695-98-5.mol

Q-VD-OPh hydrate physikalisch-chemischer Eigenschaften

Siedepunkt	808.9±65.0 °C(Predicted)
Dichte	1.346±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	-20°C
Löslichkeit	DMSO: ≥14mg/mL
pka	3.92±0.19(Predicted)
Aggregatzustand	powder
Farbe	white to light brown
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey	OOBJCYKITXPCNS-REWPJTCUSA-N

Sicherheit

WGK Germany

Gefahreninformationscode (GHS)

Q-VD-OPh hydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 μM. It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK and Boc-D-FMK . Q-VD-OPH can be used in vivo, where it has been shown to prevent ischemia-reperfusion injury-induced apoptosis. This compound, by broadly inhibiting caspases, also promotes the differentiation of leukemic blasts cells, suggesting an application in differentiation therapy of certain forms of cancer.
Verwenden
An inhibitor that is used in Alzheimer’s studies relating to caspase-6, the cysteinyl protease involved in neurodegenerative conditions. As well it is an intermediate in the formation of Palinavir, a potent HIV protease inhibitor.
Verwenden
Q-VD-OPh hydrate has been used:
- as a pan-caspase inhibitor to prevent cell death in urothelial carcinoma cells (UCC)
- to induce canonical caspase-dependent apoptosis in UC cells
- to block caspase-3 and Poly (ADP-ribose) polymerase-1 (PARP-1)
- to study the protective role of EspZ effector protein against apoptosis and necrosis in human epithelial cells
Biochem/physiol Actions
Q-VD-OPh is a potent pan-caspase inhibitor that protects cells from capsase-dependent apoptosis. Q-VD-OPh has superior aqueous stability, cell permeability, and efficacy than FMK-based caspase inhibitors and displays no cytotoxic effects alone.
target
caspase-1
Lager
+4°C
Einzelnachweise
1) Caserta?et al.?(2003),?Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties; Apoptosis,?8?345 2) Braun?et al.?(2007),?Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH; Exp. Neurol.,?206?183 3) Rebbaa?et al.?(2003),?Caspase inhibition switches doxorubicin-induced apoptosis to senescence; Oncogene,?22?2805 4) Bulatovic?et al.?(2015),?Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells; PLoS One,?10?e0120176 5) Bailey?et al. (2017),?Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis;?Cell Death Dis.,?8?e2590

Q-VD-OPh hydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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