ABC294640 Struktur

ABC294640

Bezeichnung:ABC294640

CAS-Nr915385-81-8

Englisch Name:ABC294640

CBNumberCB42624930

SummenformelC23H25ClN2O

Molgewicht380.91

MOL-Datei915385-81-8.mol

ABC294640 physikalisch-chemischer Eigenschaften

Siedepunkt	589.5±50.0 °C(Predicted)
Dichte	1.273±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	≥38.1 mg/mL in DMSO; insoluble in H2O; ≥58.9 mg/mL in EtOH
Aggregatzustand	solid
pka	14.57±0.40(Predicted)

Gefahreninformationscode (GHS)

ABC294640 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
ABC294640 is an inhibitor of sphingosine kinase 2 (SPHK2; K_i = 9.8 μM). It inhibits SPHK2 (IC₅₀ = 60 μM) without affecting SPHK1 activity up to 100 μM but does reduce SPHK1 isoform a (SPHK1a) protein levels in androgen-independent LNCaP (LNCaP-AI) cells via an SPHK1-indirect, proteasomal-dependent mechanism when used at concentrations ranging from 5 to 25 μM. ABC294640 is inactive against a panel of 20 lipid-regulated kinases at 50 μM. It decreases sphingosine-1-phosphate (S1P) production in MDA-MB-231 cells in a concentration-dependent manner. ABC294640 inhibits proliferation of a variety of cancer cells, including HepG2 liver, A-498 kidney, PANC-1 pancreas, and HT-29 colon cells (IC₅₀s = 6, 12.2, 32.8, and 48.1 μM, respectively). It reduces actin filament polymerization in, and cell migration of, A-498 cells in a scratch assay. Oral administration of ABC294640 (35 and 100 mg/kg every other day) reduces tumor growth in a mouse syngeneic model of mammary adenocarcinoma. It also reduces colonic inflammation in mouse and rat models of Crohn’s disease induced by trinitrobenzene sulfonic acid (TNBS).
Verwenden
Opaganib is used in treating iatrogenic autoimmune colitis.
Definition
ChEBI: 3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)-1-adamantanecarboxamide is an organochlorine compound.
Einzelnachweise
[1] french k j, zhuang y, maines l w, et al. pharmacology and antitumor activity of abc294640, a selective inhibitor of sphingosine kinase-2. journal of pharmacology and experimental therapeutics, 2010, 333(1): 129-139.
[2] antoon j w, white m d, meacham w d, et al. antiestrogenic effects of the novel sphingosine kinase-2 inhibitor abc294640. endocrinology, 2010, 151(11): 5124-5135.

ABC294640 Upstream-Materialien And Downstream Produkte

ABC294640 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

915385-81-8, ABC294640 Verwandte Suche:

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