Melanotan 1

Bezeichnung:Melanotan 1

CAS-Nr75921-69-6

Englisch Name:Melanotan 1

CBNumberCB4252333

SummenformelC78H111N21O19

Molgewicht1646.85

MOL-Datei75921-69-6.mol

Melanotan 1 physikalisch-chemischer Eigenschaften

Dichte	1.46±0.1 g/cm3(Predicted)
RTECS-Nr.	OS1830200
storage temp.	−20°C
Aggregatzustand	Solid
pka	4.43±0.10(Predicted)
Wasserlöslichkeit	Soluble to 0.60 mg/ml in sterile water
Sequenz	Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
InChIKey	UAHFGYDRQSXQEB-LEBBXHLNSA-N
CAS Datenbank	75921-69-6(CAS DataBase Reference)

Sicherheit

WGK Germany

Melanotan 1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.
Definition
ChEBI: Afamelanotide is a polypeptide comprising of 13 amino acids which is an analogue of alpha-melanocyte stimulating hormone. It is approved as a dermatologic drug for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. It has a role as a dermatologic drug.
Allgemeine Beschreibung
[Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.
Biochem/physiol Actions
[Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.
Nebenwirkungen
The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.
Lager
Store at -20°C

Melanotan 1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

75921-69-6, Melanotan 1 Verwandte Suche:

Send Inquriy