Guvacoline Hydrobromide

Guvacoline Hydrobromide Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  Crystalline Solid

• Verwenden

  A muscarinic receptor used as nootropic agent.

• Biologische Aktivität

  guvacoline is a kind of natural alkaloid which is found in areca nuts that is related to the nootropic, arecoline. guvacoline can function as a full agonist of atrial and ileal muscarinic receptors.in vitro: in human buccal epithelial cells, guvacoline could significantly decrease the colony-formation efficiency in a dose dependent manner, with the ic50 value of 2.1 mm. besides, guvacoline could also dose-dependently reduce the amount of total free low-molecular-weight thiols (0.88 mm guvacoline caused 25% decrease) and increase the number of single strand breaks [1].

• target

  atrial and ileal muscarinic receptors

• IC 50

  2.1 mm for growth inhibition of human buccal epithelial cells

• Einzelnachweise

  [1] k. sundqvist, y. liu, j. nair, et al. cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. cancer research 49(19), 5294-5298 (1989).

Guvacoline Hydrobromide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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