DIACYLGLYCEROL KINASE INHIBITOR II Struktur

DIACYLGLYCEROL KINASE INHIBITOR II

Bezeichnung:DIACYLGLYCEROL KINASE INHIBITOR II

CAS-Nr120166-69-0

Englisch Name:DIACYLGLYCEROL KINASE INHIBITOR II

CBNumberCB4239260

SummenformelC28H25F2N3OS

Molgewicht489.58

MOL-Datei120166-69-0.mol

DIACYLGLYCEROL KINASE INHIBITOR II physikalisch-chemischer Eigenschaften

Schmelzpunkt	228-230 °C
Siedepunkt	637.1±65.0 °C(Predicted)
Dichte	1.36±0.1 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	0.1 M HCl: slightly soluble
Aggregatzustand	solid
pka	11.24±0.20(Predicted)
Farbe	pale yellow

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3

Gefahreninformationscode (GHS)

DIACYLGLYCEROL KINASE INHIBITOR II Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
R-59-949 is an inhibitor of diacylglycerol kinase α (DGK-α) with an IC₅₀ value of 300 nM in isolated platelet plasma membranes using exogenous diacylglycerol as a substrate. DGK-α inhibition with R-59-949 increases diacylglycerol-dependent PKC activity, serotonin secretion, and aggregation of thrombin-stimulated platelets. R-59-949 inhibits DGK-α activity induced by platelet-derived growth factor (PDGF) in intact vascular smooth muscle cells (VSMCs). It inhibits high K⁺- and glucose-induced insulin secretion in MIN6 pancreatic β-cells in a dose-dependent manner. In vivo, administration of R-59-949 prevents retinal neovascularization in a mouse model of oxygen-induced retinopathy.
Verwenden
Diacylglycerol Kinase Inhibitor II has been used to determine tumor-induced inhibition with genetically modified cytotoxic T cells expressing chimeric antigen receptors (CAR). It has also been used to induce pAkt and PKR-like extracellular signal-regulated kinase (pErk) signals in T-cell acute lymphoblastic leukemia (T-ALL) cells.
Definition
ChEBI: 3-[2-[4-[bis(4-fluorophenyl)methylidene]-1-piperidinyl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one is a diarylmethane.
Biochem/physiol Actions
Diacylglycerol kinase inhibitor. Inhibits formation of [38P]1-Oleoyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC50 = 3.3 μM.

DIACYLGLYCEROL KINASE INHIBITOR II Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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