1,4,7-Triazacyclononane

Bezeichnung:1,4,7-Triazacyclononane

CAS-Nr4730-54-5

Englisch Name:1,4,7-Triazacyclononane

CBNumberCB4234922

SummenformelC6H15N3

Molgewicht129.2

MOL-Datei4730-54-5.mol

1,4,7-Triazacyclononane physikalisch-chemischer Eigenschaften

Schmelzpunkt	42-45 °C (lit.)
Siedepunkt	110-130 °C/7 mmHg (lit.)
Dichte	0.9987 (rough estimate)
Brechungsindex	1.4620 (estimate)
Flammpunkt	>230 °F
storage temp.	2-8°C
Wasserlöslichkeit	Soluble in water
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
pka	10.57±0.20(Predicted)
Aggregatzustand	crystal
Farbe	white
BRN	773877
InChIKey	ITWBWJFEJCHKSN-UHFFFAOYSA-N

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34
S-Sätze:	26-36/37/39-45
RIDADR	UN 3259 8/PG 2
WGK Germany	3
F	3-10-34
HazardClass	8
PackingGroup	III
HS Code	2933998090

Gefahreninformationscode (GHS)

1,4,7-Triazacyclononane Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
1,4,7-Triazacyclononane, known as "TACN" which is pronounced "tack-en," is a cyclic organic compound with the formula C6H12(NH)3. TACN is derived, formally speaking, from cyclononane by replacing three equidistant CH2 groups with NH groups. TACN is one of the oligomers derived from aziridine, C2H4NH. Other members of the series include diazacyclohexane, C4H8(NH)2, and the cyclic tetramer 1,4,7,10-tetraazacyclododecane.
Chemische Eigenschaften
White - light yellow solid
Verwenden
Starting material for the synthesis of 1,4,7-trifunctionalized derivatives which have applications in metal complexation.
Verwenden
1,4,7-Triazacyclononane (TACN) is a versatile platform from which various ligands can be derived to form effective chelators for (radio)copper(II) complexation. The ability of TACN-derivatives to form highly stable complexes with copper(II) is greatly influenced by the number and type of substituents on the macrocyclic ring. The formed copper(II) complexes show a broad variability in their thermodynamic stability and kinetic inertness, varying in structure from square-pyramidal to distorted octahedral. TACN-based BFCAs have also been used for indirect radiolabelling of biomolecules, rendering them suitable for imaging and therapy.
Definition
ChEBI: 1,4,7-triazonane is a saturated organic heteromonocyclic parent, a crown amine and an azacycloalkane.
synthetische
The ligand is prepared from diethylene triamine as follows by macrocyclization using ethyleneglycol ditosylate.
H2NCH2CH2NHCH2CH2NH2 + 3 TsCl → Ts(H)NCH2CH2N(Ts)CH2CHH2N(H)Ts + 3 HCl Ts(H)NCH2CH2N(Ts)CH2CH2N(H)Ts + 2 NaOEt → Ts(Na)NCH2CH2N(Ts)CH2CH2N(Na)Ts Ts(Na)NCHH2CH2N(Ts)CH2CH2N(Na)Ts + TsOCH2CH2OTs + → [(CH2CH2N(Ts)]3 + 2 NaOTs [(CH2CH2N(Ts)]3 + 3 H2O → [CH2CH2NH]3 + 3 HOTs
Application
Starting material for the synthesis of 1,4,7-trifunctionalized derivatives which have applications in metal complexation.
Possible reagent for compleximetric titrations with high cation-binding selectivity.

1,4,7-Triazacyclononane Upstream-Materialien And Downstream Produkte

1,4,7-Triazacyclononane Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

4730-54-5, 1,4,7-Triazacyclononane Verwandte Suche:

Send Inquriy