2-Isopropyl-N,2,3-trimethylbutyramid

Bezeichnung:2-Isopropyl-N,2,3-trimethylbutyramid

CAS-Nr51115-67-4

Englisch Name:2-Isopropyl-N,2,3-trimethylbutyramide

CBNumberCB4227036

SummenformelC10H21NO

Molgewicht171.28

MOL-Datei51115-67-4.mol

Synonyma

2-Isopropyl-N,2,3-trimethylbutyramid

2-Isopropyl-N,2,3-trimethylbutyramid physikalisch-chemischer Eigenschaften

Schmelzpunkt	58-61 °C
Siedepunkt	bp0.35mm 83-85°
Dichte	0.9419 (rough estimate)
Dampfdruck	0.3-0.32Pa at 25℃
FEMA	3804 \| 2-ISOPROPYL-N,2,3-TRIMETHYLBUTYRAMIDE
Brechungsindex	1.4621 (estimate)
storage temp.	Sealed in dry,Room Temperature
pka	16.46±0.46(Predicted)
Aggregatzustand	Solid
Farbe	White to Almost white
Geruch (Odor)	at 25.00 % in dipropylene glycol. mild cooling mentholic minty
Geruchsart	minty
JECFA Number	1595
Merck	14,9716
LogP	2.5 at 25℃ and pH7
CAS Datenbank	51115-67-4(CAS DataBase Reference)
EPA chemische Informationen	Butanamide, N,2,3-trimethyl-2-(1-methylethyl)- (51115-67-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38-52/53
S-Sätze:	37/39-26
HS Code	29242990

Gefahreninformationscode (GHS)

2-Isopropyl-N,2,3-trimethylbutyramide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
2-isopropyl-N,2,3-trimethylbutyramide is one nearly odorless white crystalline powder widely used as a coolant in medicinal preparations, oral care products, foodstuffs, cosmetics, and confection-eye products. It is an artificial synthesis cooling agent and could be synthesized by the Ritter reaction of 2,2-diisopropylpropionitrile (DIPPN) with methanol in the presence of acid. Compared with menthol, WS-23 is characterized by a continuous and long-lasting cooling and refreshing effect with no side effects of burning or stinging sensations. As an important additive in menthol cigarettes, WS-23 can cover up the bitter and astringent taste of cigarettes, make the cigarette feel fresh, improve the coordination and softness of cigarette smoke, and reduce the thorn in the mouth and throat. WS-23 is also compatible with other flavors and cooling agents[1].
Chemische Eigenschaften
N,2,3-Trimethyl-2-isopropylbutanamide is a white, crystalline powder,which gives a physiological cooling sensation on skin or mucosa. It is mainly used to create cooling and freshness in oral care preparations.
The material can be prepared by a Ritter reaction using N,2,3-trimethyl-2- isopropylbutyronitrile as the starting material and alkylating agents such as, for example, borates, carbonates, or phosphates.
Chemische Eigenschaften
2-Isopropyl-N-2,3-trimethylbutyramide has a cool, mint–menthol-type odor
Verwenden
2-Isopropyl-N,2,3-trimethylbutanamide is flavored compound and comprising the recount flavored compound for electronic cigarette liquid.
Verwenden
Physiological coolant in foods, beverages, tobacco products, toiletries, cosmetics and pharmaceuticals.
Definition
ChEBI: N,2,3-Trimethyl-2-(1-methylethyl)butanamide is a fatty amide.
Aroma threshold values
Aroma characteristics at 5.0%: slight cooling impact with little character.
Taste threshold values
Taste characteristics at 20 ppm: high-impacting cooling that lasts on the tongue and palate.
Handelsname
Winsense WS-23 (Renessenz).
Einzelnachweise
[1] Ze-Hong Wu. “Acute and subacute inhalation toxicity assessment of WS-23 in Sprague-Dawley rats.” Journal of Applied Toxicology (2021): 1826–1838.

2-Isopropyl-N,2,3-trimethylbutyramid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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