N-(Chlormethyl)phthalimid

Bezeichnung:N-(Chlormethyl)phthalimid

CAS-Nr17564-64-6

Englisch Name:N-(Chloromethyl)phthalimide

CBNumberCB4220350

SummenformelC9H6ClNO2

Molgewicht195.6

MOL-Datei17564-64-6.mol

Synonyma

N-(Chlormethyl)phthalimid

N-(Chlormethyl)phthalimid physikalisch-chemischer Eigenschaften

Schmelzpunkt	131-135 °C (lit.)
Siedepunkt	305.2±25.0 °C(Predicted)
Dichte	1.3228 (rough estimate)
Brechungsindex	1.5790 (estimate)
storage temp.	2-8°C
Löslichkeit	chloroform: soluble50mg/mL
Aggregatzustand	powder to crystal
pka	-2.63±0.20(Predicted)
Farbe	White to Almost white
Wasserlöslichkeit	slightly soluble
BRN	140942
InChI	InChI=1S/C9H6ClNO2/c10-5-11-8(12)6-3-1-2-4-7(6)9(11)13/h1-4H,5H2
InChIKey	JKGLRGGCGUQNEX-UHFFFAOYSA-N
SMILES	C1(=O)C2=C(C=CC=C2)C(=O)N1CCl
CAS Datenbank	17564-64-6(CAS DataBase Reference)
NIST chemische Informationen	N-(chloromethyl)phthalimide(17564-64-6)
EPA chemische Informationen	1H-Isoindole-1,3(2H)-dione, 2-(chloromethyl)- (17564-64-6)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-52/53-43-22
S-Sätze:	26-36-37/39-61-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
F	9-21
TSCA	Yes
HS Code	29251995

Gefahreninformationscode (GHS)

N-(Chloromethyl)phthalimide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
white crystalline powder
Verwenden
N-(Chloromethyl)phthalimide is used as an agrochemical and medicine intermediates and is used in organic synthesis. Microporous membranes prepared from chemically modified polysulfone, which is a derivative of this compound have better streaming potential.
Application
N-(Chloromethyl)phthalimide is a chlorine derivative of Phthalimide. Phthalimide and its derivatives are essential compounds in diverse fields. In pharmaceuticals, they are used as an intermediate material. In the medical field, they are used to synthesize compounds with antimicrobial activity, androgens, and other agents for treating tumor necrosis factor. Certain phthalimide derivatives are used as herbicides and to reduce bacterial contamination. They are widely used in industries to produce pesticides, plastics, resins, and surfactants. The N-substitution of the Phthalimide has a hypsochromic effect on color change and better color yields on poly fabrics because of the electron-donating property of the methyl group and the higher hydrophobicity of Phthalimide. Its chlorine derivative is used as an intermediate for producing medicine, pharmacy, dyes, pesticides, fire retardants, and photocopying chemicals. In particular, N-(bromomethyl)phthalimide and N-(chloromethyl)phthalimide play a vital role in anti-inflammatory, analgesic, and hypolipidimic activities[1].
läuterung methode
Purify the imide by recrystallisation from EtOAc or CCl4 or via the 1:1 complex with pyridine [Sakellarios J Am Chem Soc 70 2822 1948, B.hme et al. Chem Ber 92 1258 1959]. [Beilstein 21/10 V 372.]
Einzelnachweise
[1] V. Balachandran , S. Rajeswari, S. Lalitha . “Density functional theory, comparative vibrational spectroscopic studies, NBO, HOMO–LUMO analyses and thermodynamic functions of N-(bromomethyl)phthalimide and N-(chloromethyl)phthalimide.” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 91 (2012): Pages 146-157.

N-(Chloromethyl)phthalimide Upstream-Materialien And Downstream Produkte

N-(Chlormethyl)phthalimid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

17564-64-6, N-(Chloromethyl)phthalimide Verwandte Suche:

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