PROFLAVINE Struktur

Proflavin

Bezeichnung:Proflavin

CAS-Nr92-62-6

Englisch Name:PROFLAVINE

CBNumberCB42131119

SummenformelC13H11N3

Molgewicht209.25

MOL-Datei92-62-6.mol

Synonyma

Proflavin

Proflavin physikalisch-chemischer Eigenschaften

Schmelzpunkt	281° (Schpff); mp 288° (Albert)
Siedepunkt	338.61°C (rough estimate)
Dichte	1.1847 (rough estimate)
Brechungsindex	1.6000 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Wasserlöslichkeit	Soluble in water
Löslichkeit	DMSO: 23 mg/mL (109.92 mM);Ethanol: 2 mg/mL (9.56 mM)
pka	9.65(at 20℃)
Aggregatzustand	powder to crystal
Farbe	Light yellow to Brown
EPA chemische Informationen	3,6-Acridinediamine (92-62-6)

Sicherheit

HS Code	2933.99.4600
Giftige Stoffe Daten	92-62-6(Hazardous Substances Data)
Toxizität	LD50 s.c. in mice: 0.14 g/kg (Rubbo)

Gefahreninformationscode (GHS)

PROFLAVINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Definition
ChEBI: An aminoacridine that is acridine that is substituted by amino groups at positions 3 and 6. A slow-acting bacteriostat that is effective against many Gram-positive bacteria (but ineffective against spores), its salts were formerly used for treatment of bur s and infected wounds.
Sicherheitsprofil
Poison by intravenous, intraperitoneal, and subcutaneous routes. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also other diaminoacridine entries.
Enzyminhibitor
This dye (FWfree-base = 209.25 g/mol; CAS 92-62-6; orange-red solid; M.P. = 281 or 288°C; soluble in water; pKa = 9.65; solutions are light sensitive; insoluble in organic solvents such as benzene, diethyl ether, and chloroform), also known as proflavin and 3,6-acridinediamine, is a mutagen that intercalates in double-stranded DNA, inhibiting both DNA and RNA biosynthesis. Proflavine can also participate in the photooxidation of proteins (e.g., dopa decarboxylase. In addition, proflavine can inhibit a number of enzymes directly. For xample scriflavine, a mixture of proflavine with 3,6-diamino-10-methylacridinium chloride, inhibits protein kinase C. Target(s): L-amino-acid oxidase; carbonic anhydrase, or carbonate dehydratase, Ki ≈ 10 mM; chymotrypsin; DNA (cytosine-5-)-methyltransferase; DNA-directed RNA polymerase; dopa decarboxylase; F1Fo ATPase, or F1Fo ATP synthase, or H+-transporting two-sector ATPase; ficain, or ficin; glutamate decarboxylase; lysozyme; monoamine oxidase; NADH:cytochrome b5 reductase; nucleoside-triphosphatase, nuclear-envelope; papain; poly(ADP-ribose) glycohydrolase; polynucleotide adenylyltransferase, or poly(A) polymerase; pyruvate kinase; RNA-directed DNA polymerase; thrombin; tRNA adenylytltransferase; tRNA (guanine-N2-)-methyltransferase; tRNA cytidylyltransferase; tRNA methyltransferases; tRNA nucleotidyltransferase; and trypsin.
läuterung methode
Proclavine (3,6-diaminoacridine) [92-62-6] M 209.2, m 284-286o, pK 1 -2.7, pK 2 0 . 5 5 , pK 3 9.49. It crystallises from aqueous MeOH. The picrate crystallises from aqueous pyridine with m ~185o. [Beilstein 22 H 487, 22 I 649, 22 II 397, 22 III/IV 5487, 22/11 V 322.] For proflavin see 3,6-diaminoacridine hydrochloride.

Proflavin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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