Latanoprost acid

Bezeichnung:Latanoprost acid

CAS-Nr41639-83-2

Englisch Name:Latanoprost acid

CBNumberCB4208385

SummenformelC23H34O5

Molgewicht390.51

MOL-Datei41639-83-2.mol

Latanoprost acid physikalisch-chemischer Eigenschaften

Siedepunkt	609.1±50.0 °C(Predicted)
Dichte	1.159±0.06 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	DMSO: freely soluble
pka	4.76±0.10(Predicted)
Aggregatzustand	Oil
Farbe	pale yellow, oil
Optische Aktivität	[α]/D 26.0 to 36.0°, c =0.1 in methanol
Stabilität	Hygroscopic
InChIKey	HNPFPERDNWXAGS-NFVOFSAMSA-N
SMILES	C(O)(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1

Sicherheit

WGK Germany	3
HS Code	2937500000

Gefahreninformationscode (GHS)

Latanoprost acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF_2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC₅₀ of 3.6 nM for human FP receptors, which is twice the potency of PGF_2α. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.
Chemische Eigenschaften
Pale Yellow Oil
Verwenden
A metabolite of Latanoprost. Potent, selective FP prostanoid receptor agonist. F-series Prostaglandin analog. 200 times as potent as isopropyl ester form. Latanoprost USP Related Compound E.
Definition
ChEBI: Latanoprost free acid is a prostaglandin Falpha that is an analogue of prostaglandin F2alpha in which the pentyl group has been replaced by 2-phenylethyl and where the the 13,14-double bond has undergone formal hydrogenation. Its isopropyl ester prodrug, latanoprost, is used in the treatment of open-angle glaucoma and ocular hypertension. It has a role as an antiglaucoma drug, an antihypertensive agent and an EC 4.2.1.1 (carbonic anhydrase) inhibitor. It is a prostaglandins Falpha and a hydroxy monocarboxylic acid.
Biochem/physiol Actions
Potent, selective FP prostanoid receptor agonist, F-series prostaglandin analog. 200 times as potent as isopropyl ester form.

Latanoprost acid Upstream-Materialien And Downstream Produkte

Latanoprost acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

41639-83-2, Latanoprost acid Verwandte Suche:

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