LEUROSINE

LEUROSINE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Vinqa rosea yields this complex dimeric alkaloid which forms colourless crystals that are best purified by recrystallization from acetonitrile. It crystallizes with 8 moles of H20 and loses solvent when heated at In-5°C. It is also dextro? rotatory with [α]²⁶_D + n° (CHCI3)’ A crystalline SUlphate is known which has m.p. 238-242°C (dec.) and [α]_D - 8.3° (MeOH). The N(b)-oxide is identical with pleurosine (q.v.).

• Verwenden

  Antineoplastic.

• Verwenden

  Vinleurosine is an antitumor compound derived from Vinca Rosea.

• Definition

  ChEBI: Leurosine is a vinca alkaloid.

• Einzelnachweise

  Svoboda., J. Amer. Pharm. Assoc., 47,834 (1959)
  Neuss et al., J. Amer. Chern. Soc., 81,4754 (1959)
  Revised structure:
  Neuss et al., Tetrahedron Lett., 783 (1968)
  

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