4-Bromo-2-hydroxybenzoic acid

Bezeichnung:4-Bromo-2-hydroxybenzoic acid

CAS-Nr1666-28-0

Englisch Name:4-Bromo-2-hydroxybenzoic acid

CBNumberCB4196824

SummenformelC7H5BrO3

Molgewicht217.02

MOL-Datei1666-28-0.mol

4-Bromo-2-hydroxybenzoic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	164-165°C
Siedepunkt	330.2±32.0 °C(Predicted)
Dichte	1.861±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	2.71±0.10(Predicted)
Aggregatzustand	powder
Farbe	Orange
InChI	InChI=1S/C7H5BrO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,(H,10,11)
InChIKey	FYAKLZKQJDBBKW-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC=C(Br)C=C1O
CAS Datenbank	1666-28-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	22-52/53
S-Sätze:	22-24/25-61
RIDADR	2811
WGK Germany	3
HazardClass	IRRITANT
PackingGroup	Ⅲ
HS Code	2918290090

Gefahreninformationscode (GHS)

4-Bromo-2-hydroxybenzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
4-Bromo-2-hydroxybenzoic acid is a solid at normal temperature and pressure. It is stable at normal temperature and decomposes into phenol and carbon dioxide after rapid heating. It has some acidic properties.
Verwenden
2-Hydroxy-4-bromobenzoic acid is used as an anti-scorch agent in drug molecules and rubber industry, as well as an intermediate in the production of ultraviolet absorbers and foaming agents.
Synthese
Under nitrogen atmosphere, add copper (II) bromide (8.8 g, 39.4 mmol, 1.2 equivalents), acetonitrile (50 ml), and 4-aminosalicylic acid (5.1 g, 49.5 mmol) to the vacuum-dried reaction flask, 1.5 equivalent). The reaction mixture was cooled to 0°C, and 2-hydroxy-4-bromobenzoic acid precursor (5.0 g, 32.6 mmol, 1.0 equiv) was added portion-wise. Additional acetonitrile (25 mL) was added to the mixture and stirred at 0 °C for 2 h. The organic extracts were combined and washed with 20% aqueous hydrochloric acid, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was dissolved in diethyl ether, and the resulting solution was extracted with 15% sodium hydroxide aqueous solution. The aqueous solution was washed with diethyl ether, acidified to pH 1 with 6N hydrochloric acid aqueous solution, and the mixture was extracted with diethyl ether. The combined organic extracts were washed with brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was treated with chloroform, and the precipitate collected by filtration was 4-Bromo-2-hydroxybenzoic acid.

4-Bromo-2-hydroxybenzoic acid Upstream-Materialien And Downstream Produkte

4-Bromo-2-hydroxybenzoic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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