2-Butyl-4-chloro-5-formylimidazole

Bezeichnung:2-Butyl-4-chloro-5-formylimidazole

CAS-Nr83857-96-9

Englisch Name:2-Butyl-4-chloro-5-formylimidazole

CBNumberCB4185349

SummenformelC8H11ClN2O

Molgewicht186.64

MOL-Datei83857-96-9.mol

2-Butyl-4-chloro-5-formylimidazole physikalisch-chemischer Eigenschaften

Schmelzpunkt	97-100 °C(lit.)
Siedepunkt	384.1±22.0 °C(Predicted)
Dichte	1.240
Dampfdruck	0.001Pa at 25℃
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	soluble in methanol
Aggregatzustand	Powder to crystal
pka	8.87±0.10(Predicted)
Farbe	Pale Yellow to Brown
Wasserlöslichkeit	slightly soluble
InChIKey	JLVIHQCWASNXCK-UHFFFAOYSA-N
LogP	2.5 at 25℃ and pH7.1
Oberflächenspannung	58.3mN/m at 1.2g/L and 20℃
CAS Datenbank	83857-96-9(CAS DataBase Reference)
EPA chemische Informationen	2-Butyl-5-chloroimidazole-4-carbaldehyde (83857-96-9)

Sicherheit

Kennzeichnung gefährlicher	Xi,N
R-Sätze:	43-51/53
S-Sätze:	24-37-61
RIDADR	UN 3077 9/PG 3
WGK Germany	2
HazardClass	IRRITANT
PackingGroup	III
HS Code	29339900

Gefahreninformationscode (GHS)

2-Butyl-4-chloro-5-formylimidazole Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R43:Sensibilisierung durch Hautkontakt möglich.
R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S24:Berührung mit der Haut vermeiden.
S37:Geeignete Schutzhandschuhe tragen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
2-Butyl-4-chloro-5-formylimidazole is an API intermediate used as an intermediate for the anti-hypertensive drug Chlosartan. It can be used in the chemical manufacture of many APIs and advanced intermediates. With the help of this chemical, a number of other chemicals can be manufactured that have further applications in industries such as Losartan manufacturing.
Chemische Eigenschaften
2-Butyl-4-chloro-5-formylimidazole is Yellow Solid
Verwenden
2-Butyl-4-chloro-5-formylimidazole is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists
Verwenden
2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde may be used in the preparation of the following symmetrical esters of dialkyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate:
- dimethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- diethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- diisopropyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- diisobutyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- di-tert-butyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- bis(2-methoxyethyl) 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Application
2-Butyl-4-chloro-1H-imidazole-5-carboxaldehyde (Losartan EP Impurity D) is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists. Losartan USP Related Compound A.
Synthesis Reference(s)
The Journal of Organic Chemistry, 64, p. 8084, 1999 DOI: 10.1021/jo9824910
Synthese
2-Butyl-4-chloro-5-formylimidazole was synthesised as follows: Performing condensation reaction of pentamidine hydrochloride with glyoxal and controlling the pH value of the system in the range of 6.0-7.5; after the reaction terminates, arousing dehydration reaction of the compound of formula III, thereby obtaining 2-butyl-1H-imidazole-5(4H)-ketone; and finally, reacting 2-butyl-1H-imidazole-5(4H)-ketone with N,N-dimethylformamide in the presence of phosphorus oxychloride, thereby obtaining 2-butyl-4-chloro-5-formylimidazole.
Lager
2-Butyl-4-chloro-5-formylimidazole is soluble in DMF, DMSO, Ethanol and Methanol.

2-Butyl-4-chloro-5-formylimidazole Upstream-Materialien And Downstream Produkte

2-Butyl-4-chloro-5-formylimidazole Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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