DL-BUTHIONINE-[S,R]-SULFOXIMINE Struktur

DL-BUTHIONINE-[S,R]-SULFOXIMINE

Bezeichnung:DL-BUTHIONINE-[S,R]-SULFOXIMINE

CAS-Nr5072-26-4

Englisch Name:DL-BUTHIONINE-[S,R]-SULFOXIMINE

CBNumberCB4184630

SummenformelC8H18N2O3S

Molgewicht222.31

MOL-Datei5072-26-4.mol

DL-BUTHIONINE-[S,R]-SULFOXIMINE physikalisch-chemischer Eigenschaften

Schmelzpunkt	215 °C (dec.)(lit.)
Siedepunkt	382.3±52.0 °C(Predicted)
Dichte	1.29±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	H₂O: 50 mg/mL, clear, colorless
Aggregatzustand	Fluffy Powder
Farbe	White
Merck	13,1520
BRN	2367136
CAS Datenbank	5072-26-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	EK7713435
F	10
HS Code	29309090

Gefahreninformationscode (GHS)

DL-BUTHIONINE-[S,R]-SULFOXIMINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
DL-Buthionine-sulfoximine is suitable for use to:
- examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
- investigate the effect of BSO on development of bovine embryos
- inhibit GSH in several studies
- investigate the effect of GSH synthesis on oocyte maturation
It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH
Verwenden
A potent and specific inhibitor of alpha-glutamyl cysteine synthetase
Verwenden
Biological tool for depletion of glutathione.
Definition
ChEBI: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.
Allgemeine Beschreibung
DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.
Biochem/physiol Actions
DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).

DL-BUTHIONINE-[S,R]-SULFOXIMINE Upstream-Materialien And Downstream Produkte

DL-BUTHIONINE-[S,R]-SULFOXIMINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5072-26-4, DL-BUTHIONINE-[S,R]-SULFOXIMINE Verwandte Suche:

Send Inquriy