Divalproex sodium

Bezeichnung:Divalproex sodium

CAS-Nr76584-70-8

Englisch Name:Divalproex sodium

CBNumberCB4149527

SummenformelC8H17NaO2

Molgewicht168.21

MOL-Datei76584-70-8.mol

Divalproex sodium physikalisch-chemischer Eigenschaften

Schmelzpunkt	222 °C
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	White
CAS Datenbank	76584-70-8(CAS DataBase Reference)

Sicherheit

HS Code

2915900000

Gefahreninformationscode (GHS)

Divalproex sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Divalproex is a prodrug form of valproic acid that contains valproic acid and valproate sodium. Formulations containing divalproex exhibit delayed gastrointestinal absorption and are converted to valproic acid in the intestine, which reduces gastric irritation and nervous system side effects. Formulations containing divalproex are widely used for the treatment of seizures and bipolar disorder.
Chemische Eigenschaften
White Solid
Originator
Depakote,Abbott
Verwenden
Anticonvulsant; Bipolar Agent
Verwenden
Antiepileptic; Anticonvulsant that also acts as a mood stabilizer for those with bipolar disorder.
Verwenden
Divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. In rare cases, it is also used as a treatment for major depressive disorder, and increasingly taken long-term for prevent
Definition
ChEBI: A mixture of valproic acid and its sodium salt in a 1:1 molar ratio. It is used for the management and treatment of seizure disorders, mania, and prophylactic treatment of migraine headache.
Manufacturing Process
Dipropyl acetic acid or valproic acid may be prepared the next way. Propylbromide is mixed with cyanacetic acid in the presence of sodium ethylate, made from absolute ethanol and sodium. By that prepared α,α- dipropylcyanacetic acid ethyl ester is saponified with equimolecular amounts of NaOH to give dipropylacetonitril. The desired dipropylacetic acid is produced by saponification of dipropylacetonitryl with aquatic NaOH. It is colorless liquid. BP 219°-220°C.
Sodium salt of this acid may be prepared by adding of equivalent of NaOH.
Trademarks
Depakote (Abbott）.
Therapeutic Function
Anticonvulsant
Clinical Use

Treatment of manic episodes associated with bipolar disorder
Migraine prophylaxis (unlicensed)
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Antibacterials: metabolism possibly inhibited by erythromycin; avoid with pivmecillinam; concentration reduced by carbapenems - avoid.
Antidepressants: avoid with St John’s wort.
Antiepileptics: concentration reduced by carbamazepine; concentration of active carbamazepine metabolite increased; increased concentration of lamotrigine, phenobarbital, rufinamide and possibly ethosuximide; sometimes reduces concentration of active metabolite of oxcarbazepine; alters phenytoin concentration; phenytoin and phenobarbital reduce valproate concentration; hyperammonaemia and CNS toxicity with topiramate.
Antipsychotics: increased neutropenia with olanzapine; possibly increases or decreases concentration of clozapine; possibly increases quetiapine concentration.
Ciclosporin: variable ciclosporin blood level response.
Sodium oxybate: concentration of sodium oxybate increased.
Ulcer-healing drugs: metabolism inhibited by cimetidine, increased concentration.
Stoffwechsel
Valproic acid is extensively metabolised in the liver, a large part by glucuronidation (up to 60
%) and the rest by a variety of complex pathways (up to 45
%). It is excreted in the urine almost entirely in the form of its metabolites; small amounts are excreted in faeces and expired air.

Divalproex sodium Upstream-Materialien And Downstream Produkte

Divalproex sodium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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