6-Chlor-7H-purin-2-ylamin

Bezeichnung:6-Chlor-7H-purin-2-ylamin

CAS-Nr10310-21-1

Englisch Name:6-Chloroguanine

CBNumberCB4143631

SummenformelC5H4ClN5

Molgewicht169.57

MOL-Datei10310-21-1.mol

Synonyma

6-Chlor-7H-purin-2-ylamin

6-Chlor-7H-purin-2-ylamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300 °C (lit.)
Siedepunkt	279.76°C (rough estimate)
Dichte	1.4937 (rough estimate)
Brechungsindex	1.6110 (estimate)
storage temp.	2-8°C
Löslichkeit	Solubility in 1mol/L NaOH
pka	6.65±0.20(Predicted)
Aggregatzustand	Powder
Farbe	White to yellow
Wasserlöslichkeit	1.7 g/L (20 ºC)
BRN	9626
InChI	InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
InChIKey	RYYIULNRIVUMTQ-UHFFFAOYSA-N
SMILES	N1C2C(=NC(N)=NC=2Cl)NC=1
CAS Datenbank	10310-21-1(CAS DataBase Reference)
EPA chemische Informationen	6-Chloro-2-aminopurine (10310-21-1)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	20/21/22-36/37/38
S-Sätze:	22-24/25-36-26
WGK Germany	3
RTECS-Nr.	UO7502000
F	10
Hazard Note	Irritant/Keep Cold
HazardClass	IRRITANT, KEEP COLD
HS Code	29339900

Gefahreninformationscode (GHS)

6-Chloroguanine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).
Chemische Eigenschaften
white to light yellow crystal powder
Verwenden
2-Amino-6-chloropurine may be used:
- in the enzymatic synthesis of 2′-deoxyguanosine
- in the synthesis of 9-alkyl purines
- in the synthesis of (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases
Verwenden
2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases.
Definition
ChEBI: 6-chloroguanine is an organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. It is a member of 2-aminopurines and an organochlorine compound.
Allgemeine Beschreibung
2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method.
Synthese
Preparation of 2-amino-6-chloropurine:
Diacetyl guanine (8.0g, 0.034 moles), triethyimethylammonium chloride (15.45g, 0.102 moles), and triethylamine (4.74 mis, 0.034 moles) were heated together with stirring in acetonitrile (70mls) to 50°C. Phosphorus oxychioride (6.34 mis, 0.068 moles) was then added and stirring continued for 4 hours. The reaction mixture was cooled and then added to aqueous sodium hydroxide solution (20g in 300mls water). The reaction mixture was heated to 80°C for 2 hours and then the volume made up to 300 mis with water. The mixture was cooled to 25°C and the pH adjuster to 7 using 10% hydrochloric acid. The resulting slurry was stirred for fifteen minutes and the product filtered off and washed with water 30 mis and then dried at 80°C under vacuum to give a cream/off white coloured product, 2-amino-6-chioropurine 4.69 g (74.6% yield).

6-Chloroguanine Upstream-Materialien And Downstream Produkte

6-Chlor-7H-purin-2-ylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

10310-21-1, 6-Chloroguanine Verwandte Suche:

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